来自 Ormosia henryi 的多聚异戊烯基异黄酮和异黄酮类化合物及其细胞毒性和抗氧化活性。
Polyprenylated isoflavanone and isoflavonoids from Ormosia henryi and their cytotoxicity and anti-oxidation activity.
机构信息
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, People's Republic of China.
出版信息
Fitoterapia. 2012 Jan;83(1):161-5. doi: 10.1016/j.fitote.2011.10.007. Epub 2011 Oct 24.
A rare naturally-occurring polyprenylated isoflavanone, designated ormosinol (1), and a new isoflavonoid glycoside, named ormosinoside (2), along with 21 known compounds were isolated from the root bark of Ormosia henryi Prain. The structures of compounds 1 and 2 were determined as 5,7,2',4'-tetrahydroxyl-6,8,5'-tri-(γ,γ-dimethylallyl)isoflavanone and isoprunetin-7-O-β-D-xylopyranosyl-(1 → 6)-β-D-glucopyranoside on the basis of a combination of 1D-, 2D-NMR and mass spectroscopic measurements. Compound 1 showed significant anti-oxidation activity against DPPH radicals (IC(50) 28.5 μM) and cancer cell line (A549, LAC, and HepG2) growth inhibitory activity with IC(50) ranging from 4.25 to 7.09 μM, while compound 2 found to be inactive to both testing systems.
从 Ormosia henryi Prain 的根皮中分离得到了一种罕见的天然多聚异戊烯基异黄酮，命名为奥罗米索林（1），以及一种新的异黄酮糖苷，命名为奥罗米索苷（2），此外还分离得到了 21 种已知化合物。根据 1D-、2D-NMR 和质谱测量的综合结果，确定化合物 1 和 2 的结构分别为 5,7,2',4'-四羟基-6,8,5'-三-(γ,γ-二甲基烯丙基)异黄酮和异牡荆素-7-O-β-D-吡喃木糖基-(1 → 6)-β-D-吡喃葡萄糖苷。化合物 1 对 DPPH 自由基（IC50 为 28.5 μM）和癌细胞系（A549、LAC 和 HepG2）生长抑制活性表现出显著的抗氧化活性，IC50 范围为 4.25 至 7.09 μM，而化合物 2 在这两种测试系统中均无活性。
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