双相谱系障碍青少年中促炎标志物和脑源性神经营养因子的初步研究结果。
Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders.
作者信息
Goldstein Benjamin I, Collinger Katelyn A, Lotrich Francis, Marsland Anna L, Gill Mary-Kay, Axelson David A, Birmaher Boris
机构信息
Department of Psychiatry, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Canada.
出版信息
J Child Adolesc Psychopharmacol. 2011 Oct;21(5):479-84. doi: 10.1089/cap.2011.0009.
Abstract
Mood symptoms in adult bipolar disorder are associated with increased proinflammatory markers and decreased brain-derived neurotrophic factor (BDNF). We examined serum interleukin-6, high-sensitivity C-reactive protein (hsCRP), and BDNF among 30 bipolar disorder adolescents. Hypomanic/manic symptoms were positively associated with hsCRP. BDNF levels were negatively associated with interleukin-6. Forty percent had cardiovascular high-risk hsCRP levels. Larger longitudinal studies are warranted.
摘要
成人双相情感障碍的情绪症状与促炎标志物增加及脑源性神经营养因子（BDNF）减少有关。我们检测了30名双相情感障碍青少年的血清白细胞介素-6、高敏C反应蛋白（hsCRP）和BDNF。轻躁狂/躁狂症状与hsCRP呈正相关。BDNF水平与白细胞介素-6呈负相关。40%的人hsCRP水平处于心血管高危状态。有必要进行更大规模的纵向研究。
相似文献
1
Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders.双相谱系障碍青少年中促炎标志物和脑源性神经营养因子的初步研究结果。
J Child Adolesc Psychopharmacol. 2011 Oct;21(5):479-84. doi: 10.1089/cap.2011.0009.
2
Cytokines, brain-derived neurotrophic factor and C-reactive protein in bipolar I disorder - Results from a prospective study.双相I型障碍中的细胞因子、脑源性神经营养因子和C反应蛋白——一项前瞻性研究的结果
J Affect Disord. 2016 Jun;197:167-74. doi: 10.1016/j.jad.2016.03.040. Epub 2016 Mar 10.
3
Brain-derived neurotrophic factor, adiponectin, and proinflammatory markers in various subtypes of depression in young men.脑源性神经营养因子、脂联素与青年男性不同类型抑郁症中的促炎标志物。
Int J Psychiatry Med. 2011;42(3):211-26. doi: 10.2190/PM.42.3.a.
4
Inflammatory markers among adolescents and young adults with bipolar spectrum disorders.双相谱系障碍青少年及青年中的炎症标志物
J Clin Psychiatry. 2015 Nov;76(11):1556-63. doi: 10.4088/JCP.14m09395.
5
Inflammatory Markers and Brain-Derived Neurotrophic Factor as Potential Bridges Linking Bipolar Disorder and Cardiovascular Risk Among Adolescents.炎症标志物和脑源性神经营养因子作为连接青少年双相情感障碍与心血管风险的潜在桥梁。
J Clin Psychiatry. 2017 Mar;78(3):e286-e293. doi: 10.4088/JCP.16m10762.
6
Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium.双相障碍患者血清脑源性神经营养因子（BDNF）和胶质细胞源性神经营养因子（GDNF）水平的改变：锂的作用。
J Affect Disord. 2014 Sep;166:193-200. doi: 10.1016/j.jad.2014.05.012. Epub 2014 May 22.
7
The Differential Levels of Inflammatory Cytokines and BDNF among Bipolar Spectrum Disorders.双相谱系障碍中炎性细胞因子和脑源性神经营养因子的差异水平
Int J Neuropsychopharmacol. 2016 Aug 12;19(8). doi: 10.1093/ijnp/pyw012. Print 2016 Aug.
8
Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood.双相情感障碍后代中的单核细胞激活、脑源性神经营养因子（BDNF）和S100B：一项从青春期到成年期的随访研究。
Bipolar Disord. 2015 Feb;17(1):39-49. doi: 10.1111/bdi.12231. Epub 2014 Jul 17.
9
Elevated levels of plasma brain derived neurotrophic factor in rapid cycling bipolar disorder patients.快速循环型双相情感障碍患者血浆脑源性神经营养因子水平升高。
Psychoneuroendocrinology. 2014 Sep;47:199-211. doi: 10.1016/j.psyneuen.2014.05.011. Epub 2014 May 27.
10
Association of Lipid Peroxidation and Brain-Derived Neurotrophic Factor with Executive Function in Adolescent Bipolar Disorder.青少年双相情感障碍中脂质过氧化与脑源性神经营养因子与执行功能的关联
Psychopharmacology (Berl). 2017 Feb;234(4):647-656. doi: 10.1007/s00213-016-4500-x. Epub 2016 Dec 12.
引用本文的文献
1
Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder.双相障碍青少年中 C 反应蛋白水平升高与皮质表面积增大和皮质厚度降低有关。
Int J Neuropsychopharmacol. 2023 Dec 18;26(12):867-878. doi: 10.1093/ijnp/pyad063.
2
Interleukin-8 and tumor necrosis factor-alpha in youth with mood disorders-A longitudinal study.青少年情绪障碍患者体内白细胞介素-8和肿瘤坏死因子-α的纵向研究
Front Psychiatry. 2022 Aug 11;13:964538. doi: 10.3389/fpsyt.2022.964538. eCollection 2022.
3
Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy.OCT 血管造影评估无临床糖尿病视网膜病变征象患者的黄斑病变：用于糖尿病视网膜病变早期筛查的放射组学特征。
BMC Ophthalmol. 2022 Jun 27;22(1):281. doi: 10.1186/s12886-022-02492-x.
4
Diabetes Exacerbates Sepsis-Induced Neuroinflammation and Brain Mitochondrial Dysfunction.糖尿病会加剧脓毒症诱导的神经炎症和脑线粒体功能障碍。
Inflammation. 2022 Dec;45(6):2352-2367. doi: 10.1007/s10753-022-01697-y. Epub 2022 Jun 10.
5
Elevated C-reactive protein among symptomatic youth with bipolar disorder.双相障碍症状性青年中 C 反应蛋白升高。
J Psychopharmacol. 2022 May;36(5):645-652. doi: 10.1177/02698811221093796.
6
Inflammatory signaling mechanisms in bipolar disorder.双相情感障碍中的炎症信号传导机制。
J Biomed Sci. 2021 Jun 11;28(1):45. doi: 10.1186/s12929-021-00742-6.
7
Gender Differences in Complete Blood Count and Inflammatory Ratios among Patients with Bipolar Disorder.双相情感障碍患者全血细胞计数及炎症指标的性别差异
Brain Sci. 2021 Mar 12;11(3):363. doi: 10.3390/brainsci11030363.
8
Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications.糖尿病视网膜病变与脑源性神经营养因子：关于其分子基础及临床应用的综述
J Ophthalmol. 2020 May 18;2020:1602739. doi: 10.1155/2020/1602739. eCollection 2020.
9
Call to action regarding the vascular-bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders.呼吁关注血管-双相关联：来自国际双相障碍学会血管工作组的报告。
Bipolar Disord. 2020 Aug;22(5):440-460. doi: 10.1111/bdi.12921. Epub 2020 Jun 8.
10
Higher Prevalence of Metabolic Syndrome in Child-adolescent Patients with Bipolar Disorder.双相情感障碍儿童青少年患者中代谢综合征的患病率更高。
Clin Psychopharmacol Neurosci. 2020 May 31;18(2):279-288. doi: 10.9758/cpn.2020.18.2.279.
本文引用的文献
1
The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met.童年期虐待和近期压力对血清脑源性神经营养因子的影响及 BDNF Val66Met 的调节作用。
Psychopharmacology (Berl). 2011 Mar;214(1):319-28. doi: 10.1007/s00213-010-1961-1. Epub 2010 Aug 12.
2
Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes.急性胰岛素诱导性低血糖对炎症指标的影响：糖尿病血管疾病加重的潜在机制。
Diabetes Care. 2010 Jul;33(7):1591-7. doi: 10.2337/dc10-0013.
3
A cohort study of the prevalence and impact of comorbid medical conditions in pediatric bipolar disorder.一项儿科双相情感障碍共病医疗状况的患病率和影响的队列研究。
J Clin Psychiatry. 2010 Nov;71(11):1518-25. doi: 10.4088/JCP.09m05585ora. Epub 2010 Jun 15.
4
A systemic toxicity index developed to assess peripheral changes in mood episodes.一种用于评估情绪发作外周变化的全身毒性指数。
Mol Psychiatry. 2010 Aug;15(8):784-6. doi: 10.1038/mp.2009.112. Epub 2010 Mar 30.
5
Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function.血清 C 反应蛋白与脑微观结构完整性和认知功能有关。
Neurology. 2010 Mar 30;74(13):1022-9. doi: 10.1212/WNL.0b013e3181d7b45b.
6
State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study.双相障碍患者脑源性神经营养因子水平的状态依赖性下降：一项荟萃分析研究。
Neurosci Lett. 2009 Dec 11;466(3):139-43. doi: 10.1016/j.neulet.2009.09.044. Epub 2009 Sep 26.
7
Medical comorbidity among youth diagnosed with bipolar disorder in the United States.美国双相情感障碍确诊青年中的医学共病情况。
J Clin Psychiatry. 2009 Oct;70(10):1461-6. doi: 10.4088/JCP.08m04871. Epub 2009 Sep 8.
8
Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States.美国双相I型障碍成年患者中的心血管疾病和高血压
Bipolar Disord. 2009 Sep;11(6):657-62. doi: 10.1111/j.1399-5618.2009.00735.x.
9
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise.运动过程中大脑释放脑源性神经营养因子的证据。
Exp Physiol. 2009 Oct;94(10):1062-9. doi: 10.1113/expphysiol.2009.048512. Epub 2009 Aug 7.
10
The potential use of biomarkers as an adjunctive tool for staging bipolar disorder.生物标志物作为双相情感障碍分期的辅助工具的潜在用途。
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1366-71. doi: 10.1016/j.pnpbp.2009.07.027. Epub 2009 Aug 8.
Zotero 插件