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[人乳头瘤病毒相关头颈部癌症]

[HPV associated head and neck cancers].

作者信息

Vourexakis Zacharias, Dulguerov Pavel

机构信息

Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, HUG, 1211 Genève 14.

出版信息

Rev Med Suisse. 2011 Oct 5;7(311):1919-22.

Abstract

The incidence of oropharyngeal squamous cell carcinoma is rising and this increase is linked to sexual behaviors. Viral and epidemiological studies have linked tonsillar and base of tongue carcinoma with a human papilloma virus (HPV) infection. The patients involved are usually younger and do not exhibit other risk factors such as smoking and alcohol abuse. HPV positive squamous cell carcinoma are associated with a better prognosis than other head and neck carcinoma. Differences in the carcinogenesis mechanisms open options for different and specific oncologic treatments and the potential for prevention of these HPV-related carcinoma by vaccination.

摘要

口咽鳞状细胞癌的发病率正在上升,这种上升与性行为有关。病毒学和流行病学研究已将扁桃体癌和舌根癌与人乳头瘤病毒(HPV)感染联系起来。所涉及的患者通常较为年轻,且不表现出吸烟和酗酒等其他风险因素。与其他头颈癌相比,HPV阳性鳞状细胞癌的预后较好。致癌机制的差异为不同的特异性肿瘤治疗提供了选择,也为通过接种疫苗预防这些HPV相关癌症提供了可能性。

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