黄单胞菌 SoxR 转录调控因子在感应氧化还原循环药物和调节保护性基因方面的新作用，这些作用对细菌在宿主植物上的应激生理和毒力具有总体意义。
Novel roles of SoxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plant.
机构信息
Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand.
出版信息
J Bacteriol. 2012 Jan;194(2):209-17. doi: 10.1128/JB.05603-11. Epub 2011 Nov 4.
Abstract
In Xanthomonas campestris pv. campestris, SoxR likely functions as a sensor of redox-cycling drugs and as a transcriptional regulator. Oxidized SoxR binds directly to its target site and activates the expression of xcc0300, a gene that has protective roles against the toxicity of redox-cycling compounds. In addition, SoxR acts as a noninducible repressor of its own expression. X. campestris pv. campestris requires SoxR both for protection against redox-cycling drugs and for full virulence on a host plant. The X. campestris model of the gene regulation and physiological roles of SoxR represents a novel variant of existing bacterial SoxR models.
摘要
在野油菜黄单胞菌野油菜致病变种中，SoxR 可能作为一种氧化还原循环药物的传感器和转录调节因子发挥作用。氧化的 SoxR 直接结合到其靶位点并激活 xcc0300 的表达，xcc0300 基因对氧化还原循环化合物的毒性具有保护作用。此外，SoxR 作为其自身表达的非诱导性阻遏物发挥作用。野油菜黄单胞菌野油菜致病变种既需要 SoxR 来保护其免受氧化还原循环药物的侵害，也需要 SoxR 来充分发挥其在宿主植物上的毒力。 SoxR 的基因调控和生理作用的野油菜黄单胞菌模型代表了现有细菌 SoxR 模型的一种新变体。
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