苯丙酮尿症患者和对照者中的赭曲霉毒素 A 和β2-微球蛋白。
Ochratoxin A and β2-microglobulin in BEN patients and controls.
机构信息
National Center of Public Health Protection, 1431 Sofia, Bulgaria.
出版信息
Toxins (Basel). 2010 Apr;2(4):780-92. doi: 10.3390/toxins2040780. Epub 2010 Apr 20.
Abstract
Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN.
摘要
赭曲霉毒素 A（OTA）是一种天然存在于不同食物中的真菌毒素。OTA 可以说是巴尔干地方性肾病（BEN）的一个风险因素。本研究的目的是：（1）在 BEN 组和对照组中检测 OTA-BEN 关联；（2）确定尿液β2-微球蛋白（一种反映肾脏重吸收功能受损的标志物）是否与 OTA 有关。BEN 患者的 OTA 血清水平明显更高。在后代中，OTA 与更高的β2-微球蛋白排泄量显著相关。2005/2006 年的 OTA 与 2008 年后 BEN 发病率的升高有关，进一步证明 OTA 是 BEN 的一个风险因素。
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