细胞外基质在代谢组织功能中的作用。
ECM roles in the function of metabolic tissues.
机构信息
Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53792, USA.
出版信息
Trends Endocrinol Metab. 2012 Jan;23(1):16-22. doi: 10.1016/j.tem.2011.09.006. Epub 2011 Nov 8.
Abstract
All metazoan cells produce and/or interact with tissue-specific extracellular matrices (ECMs). Such ECMs play important structural roles not only in connective tissues, but in all tissues in which they provide support and anchorage for cells. However, in addition to such structural roles it has become increasingly clear that the tissue-specific microenvironments formed by the ECM play instructional roles that inform the proper phenotypes and functional behaviors of specialized cell types, and recent in vivo and in vitro studies suggest that ECM components also affect metabolic function. This review summarizes data that provide insights into the roles of the ECM in informing the proper development and functioning of highly specialized cells of metabolic tissues, such as adipocytes and islet β cells.
摘要
所有后生动物细胞都会产生和/或与组织特异性细胞外基质（ECM）相互作用。这些 ECM 不仅在结缔组织中起着重要的结构作用，而且在所有组织中，它们为细胞提供支持和固定。然而，除了这些结构作用外，越来越明显的是，ECM 形成的组织特异性微环境发挥着指导作用，告知专门细胞类型的适当表型和功能行为，最近的体内和体外研究表明，ECM 成分也会影响代谢功能。本综述总结了一些数据，这些数据深入了解 ECM 在告知代谢组织中高度特化细胞（如脂肪细胞和胰岛β细胞）的正常发育和功能中的作用。
相似文献
1
ECM roles in the function of metabolic tissues.
Trends Endocrinol Metab. 2012 Jan;23(1):16-22. doi: 10.1016/j.tem.2011.09.006. Epub 2011 Nov 8.
2
Adipose tissue extracellular matrix: newly organized by adipocytes during differentiation.
Differentiation. 1998 Aug;63(4):193-200. doi: 10.1111/j.1432-0436.1998.00193.x.
3
Extracellular Matrix-Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival.
Endocrinology. 2019 Aug 1;160(8):1885-1894. doi: 10.1210/en.2019-00206.
4
Extracellular Matrix (ECM) and the Sculpting of Embryonic Tissues.
Curr Top Dev Biol. 2018;130:245-274. doi: 10.1016/bs.ctdb.2018.03.006.
5
Distinct phenotypes of cancer cells on tissue matrix gel.
Breast Cancer Res. 2020 Jul 31;22(1):82. doi: 10.1186/s13058-020-01321-7.
6
A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk.
J Vis Exp. 2019 Nov 7(153). doi: 10.3791/60486.
7
Extracellular matrix gel is necessary for in vitro cultivation of insulin producing cells from human umbilical cord blood derived mesenchymal stem cells.
Chin Med J (Engl). 2008 May 5;121(9):811-8.
8
Human mesenchymal stem cells tissue development in 3D PET matrices.
Biotechnol Prog. 2004 May-Jun;20(3):905-12. doi: 10.1021/bp034296z.
9
The influence of extracellular matrix substrata on preadipocyte development in serum-free cultures of stromal-vascular cells.
J Anim Sci. 1996 Sep;74(9):2117-28. doi: 10.2527/1996.7492117x.
10
The extracellular matrix as a multitasking player in disease.
FEBS J. 2019 Aug;286(15):2830-2869. doi: 10.1111/febs.14818. Epub 2019 Apr 11.
引用本文的文献
1
The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice.
Physiol Rep. 2025 Jul;13(13):e70424. doi: 10.14814/phy2.70424.
2
Threonine Deficiency Increases Triglyceride Deposition in Primary Duck Hepatocytes by Reducing STAT3 Phosphorylation.
Int J Mol Sci. 2024 Jul 26;25(15):8142. doi: 10.3390/ijms25158142.
3
Extracellular Matrix Expression in Human Pancreatic Fat Cells of Patients with Normal Glucose Regulation, Prediabetes and Type 2 Diabetes.
Int J Mol Sci. 2023 Jul 6;24(13):11169. doi: 10.3390/ijms241311169.
4
Collagens Regulating Adipose Tissue Formation and Functions.
Biomedicines. 2023 May 10;11(5):1412. doi: 10.3390/biomedicines11051412.
5
Extracellular matrix stiffness-The central cue for skin fibrosis.
Front Mol Biosci. 2023 Mar 8;10:1132353. doi: 10.3389/fmolb.2023.1132353. eCollection 2023.
6
Role of Heparan Sulfate in Vasculogenesis of Dental Pulp Stem Cells.
J Dent Res. 2023 Feb;102(2):207-216. doi: 10.1177/00220345221130682. Epub 2022 Oct 24.
7
Spleen extracellular matrix provides a supportive microenvironment for β-cell function.
Iran J Basic Med Sci. 2022 Sep;25(9):1159-1165. doi: 10.22038/IJBMS.2022.65233.14360.
8
Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation.
Front Bioeng Biotechnol. 2022 Aug 2;10:903907. doi: 10.3389/fbioe.2022.903907. eCollection 2022.
9
Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling.
Elife. 2021 Sep 28;10:e66635. doi: 10.7554/eLife.66635.
10
Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations.
Int J Mol Sci. 2021 Aug 29;22(17):9367. doi: 10.3390/ijms22179367.
本文引用的文献
1
Transmembrane collagen receptors.
Annu Rev Cell Dev Biol. 2011;27:265-90. doi: 10.1146/annurev-cellbio-092910-154013. Epub 2011 May 13.
2
Differential and restricted expression of novel collagen VI chains in mouse.
Matrix Biol. 2011 May;30(4):248-57. doi: 10.1016/j.matbio.2011.03.006. Epub 2011 Apr 6.
3
Basement membranes: cell scaffoldings and signaling platforms.
Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2):a004911. doi: 10.1101/cshperspect.a004911.
4
The collagen family.
Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004978. doi: 10.1101/cshperspect.a004978.
5
α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.
J Clin Invest. 2011 Feb;121(2):769-83. doi: 10.1172/JCI45096.
6
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.
Diabetes. 2011 Feb;60(2):416-26. doi: 10.2337/db10-1116.
7
Pathogenesis of liver fibrosis.
Annu Rev Pathol. 2011;6:425-56. doi: 10.1146/annurev-pathol-011110-130246.
8
Clinical and genetic aspects of Ehlers-Danlos syndrome, classic type.
Genet Med. 2010 Oct;12(10):597-605. doi: 10.1097/GIM.0b013e3181eed412.
9
Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.
Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1016-27. doi: 10.1152/ajpendo.00329.2010. Epub 2010 Sep 14.
10
Assembly of fibronectin extracellular matrix.
Annu Rev Cell Dev Biol. 2010;26:397-419. doi: 10.1146/annurev-cellbio-100109-104020.
Zotero 插件