Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.
J Am Chem Soc. 2011 Dec 14;133(49):19698-701. doi: 10.1021/ja209472h. Epub 2011 Nov 18.
The catalytic resolution of racemic cyclic amines has been achieved by an enantioselective amidation reaction featuring an achiral N-heterocyclic carbene catalyst and a new chiral hydroxamic acid cocatalyst working in concert. The reactions proceed at room temperature, do not generate nonvolatile byproducts, and provide enantioenriched amines by aqueous extraction.
通过非手性 N-杂环卡宾催化剂和一种新的手性羟肟酸共催化剂协同作用的对映选择性酰胺化反应，实现了外消旋环状胺的催化拆分。这些反应在室温下进行，不生成挥发性副产物，并通过水相萃取提供手性胺。
