用电喷雾电离质谱法对二氮烯二硝酸盐一氧化氮供体（NONOates）进行表征。

Characterization of diazeniumdiolate nitric oxide donors (NONOates) by electrospray ionization mass spectrometry.

机构信息

Department of Chemistry, The University of Akron, Akron, Ohio, USA.

出版信息

Rapid Commun Mass Spectrom. 2011 Dec 15;25(23):3581-6. doi: 10.1002/rcm.5273.

PMID:22095507

Abstract

Diazeniumdiolates (also called NONOates) have been analyzed by electrospray ionization mass spectrometry (ESI-MS). The samples used are commercially available and included Diethylamine NONOate, DETA NONOate, Spermine NONOate, MAHMA NONOate, PROLI NONOate, Dipropylenetriamine NONOate, PAPA NONOate, and Sulpho NONOate. These compounds have been found to ionize upon ESI by protonation, deprotonation and sodiation. The MS(n) experiments provided strong evidence that such ions release NO, HNO, N(2)O, NO(2), N(2)O(2), N(3)O(3), N(4)O(3) and N(4)O(4) when collisionally activated. Thus, the facile donation of NO units is a property of such compounds. Negative-mode mass spectrometry has been particularly useful for the analysis of most of the NONOates studied here. The experiments have demonstrated the capabilities of mass spectrometry, along with CAD (MS/MS), to detect and characterize such compounds.

摘要

Diazeniumdiolates（也称为 NONOates）已通过电喷雾电离质谱（ESI-MS）进行了分析。所用样品均为市售产品，包括二乙胺 NONOate、DETA NONOate、精胺 NONOate、MAHMA NONOate、PROLI NONOate、二丙撑三胺 NONOate、PAPA NONOate 和磺基 NONOate。研究发现，这些化合物在 ESI 中通过质子化、去质子化和钠化而发生离子化。MS(n)实验提供了有力的证据表明，当这些离子发生碰撞时，会释放出 NO、HNO、N(2)O、NO(2)、N(2)O(2)、N(3)O(3)、N(4)O(3) 和 N(4)O(4)。因此，此类化合物易于提供 NO 单元。负离子模式质谱分析对这里研究的大多数 NONOates 尤其有用。实验证明了质谱法（结合 CAD（MS/MS））具有检测和表征此类化合物的能力。