miR-29 抑制可增强弹性蛋白单倍不足的细胞和生物工程血管中的弹性蛋白水平——简短报告。
Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.
机构信息
Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA.
出版信息
Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):756-9. doi: 10.1161/ATVBAHA.111.238113. Epub 2011 Nov 17.
Abstract
OBJECTIVE
The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN.
METHODS AND RESULTS
miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels.
CONCLUSION
miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.
摘要
目的
本研究旨在确定拮抗 microRNA（miR）-29 是否能增加缺乏弹性蛋白（ELN）的细胞和组织中的 ELN 水平。
方法和结果
miR-29 模拟物降低了成纤维细胞和平滑肌细胞中的 ELN 水平，而 miR-29 抑制则增加了 ELN 水平。miR-29 的拮抗作用也增加了 ELN 部分缺失患者的细胞和生物工程人血管中的 ELN 水平。
结论
miR-29 拮抗作用可能在 ELN 缺乏的情况下促进 ELN 水平的增加。
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