心肌梗死后心尖球形综合征患者肱动脉血流介导的扩张功能。
Brachial artery flow-mediated dilation in patients with Tako-tsubo cardiomyopathy.
机构信息
Department of Cardiology, Moscow State University of Medicine and Dentistry, Russia.
出版信息
Am J Med. 2011 Dec;124(12):1176-9. doi: 10.1016/j.amjmed.2011.05.033.
BACKGROUND
Tako-Tsubo cardiomyopathy (TTC) is a heart syndrome associated with transient myocardial contractile dysfunction. The pathogenesis of TTC remains unclear. The purpose of this study was to investigate brachial artery flow-mediated dilation (FMD) in patients with TTC.
METHODS
The results of FMD tests of 4 women with TTC were compared with the results from 18 women with ST-elevation acute myocardial infarction (STEMI) and from 26 healthy female volunteers. FMD tests in all patients were performed within 24 hours of admission and again at 1-3 weeks as a follow-up.
RESULTS
The FMD levels were significantly lower at the acute phase in patients with TTC than in patients with STEMI and in healthy volunteers (P <.01). After 1-3 weeks, the FMD test results of patients with TTC had greatly increased, and no significant differences were found between these results and the results from patients with STEMI (P >.05). Also, there were no significant differences in the FMD test results between the group of patients with TTC and the group of healthy volunteers (P >.05).
CONCLUSIONS
There is a pronounced and reversible endothelial dysfunction in patients with TTC, which can impair myocardial perfusion.
背景
心尖球形综合征（Tako-Tsubo 心肌病，TTC）是一种与短暂性心肌收缩功能障碍相关的心脏综合征。TTC 的发病机制仍不清楚。本研究旨在探讨 TTC 患者的肱动脉血流介导的扩张（FMD）。
方法
将 4 例 TTC 患者的 FMD 检测结果与 18 例 ST 段抬高型急性心肌梗死（STEMI）患者和 26 名健康女性志愿者的检测结果进行比较。所有患者均在入院后 24 小时内和 1-3 周的随访时进行 FMD 检测。
结果
TTC 患者在急性期的 FMD 水平明显低于 STEMI 患者和健康志愿者（P<.01）。1-3 周后，TTC 患者的 FMD 检测结果显著升高，与 STEMI 患者的结果相比无显著差异（P>.05）。此外，TTC 患者组与健康志愿者组的 FMD 检测结果无显著差异（P>.05）。
结论
TTC 患者存在明显且可逆转的内皮功能障碍，可损害心肌灌注。
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