人类结肠癌中溴结构域蛋白 BRD4 的异常表观遗传调控。
Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer.
机构信息
Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.
出版信息
J Mol Med (Berl). 2012 May;90(5):587-95. doi: 10.1007/s00109-011-0837-0. Epub 2011 Nov 27.
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer.
溴结构域蛋白 BRD4 参与细胞增殖和细胞周期进程，主要通过其在乙酰化染色质依赖性调节靶向基因转录中的作用。在这里，我们表明 BRD4 在人类结肠癌细胞系和原发性肿瘤中经常因异常启动子超甲基化而下调。在这些结肠癌细胞系中外源性表达 BRD4 显著减少体内肿瘤生长，表明 BRD4 在人类结肠癌中的作用。
Zotero 插件