Department of Neurosurgery, Chang Gung University, Chang Gung Medical College, and Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.
World Neurosurg. 2012 Feb;77(2):352-6. doi: 10.1016/j.wneu.2011.06.013. Epub 2011 Nov 7.
Percutaneous balloon compression (PBC) is an alternative surgical treatment for trigeminal neuralgia refractory to carbamazepine. PBC is the preferred procedure for some patients. However, to our knowledge, the clinical results of repeat PBC have not been reported thus far.
The aim of this study was to evaluate the outcomes of and the complication rates associated with repeat PBC performed for recurrent trigeminal neuralgia, over an 8-year study period.
Until July 2004, we performed PBC in 272 consecutive patients with typical symptoms of unilateral trigeminal neuralgia at our hospital. PBC was successful in 43 patients, and they did not experience any pain for at least 3 months; however, symptoms recurred later. Among these 43 patients, 32 underwent a repeat (second) PBC whereas 11 received pharmacologic treatment. The repeat PBC was performed between March 2001 and December 2004, and the patients were followed up till June 2010.
Thirty-two patients with recurrent trigeminal neuralgia participated in this study. The follow-up period ranged from 5.08 to 8.75 years (mean, 6.43 years). After the repeat PBC, 30 patients (93.8%) experienced immediate relief from neuralgia. None of the patients developed transient diplopia or anesthesia dolorosa. Although 2 patients (6.2%) experienced severe hypoesthesia, they could tolerate it. Six patients (18.8%) showed limited mandibular activity. No major surgical or anesthetic complication was observed, and death did not occur. Pain did not recur in any patient for 3 months after the surgery. The symptoms recurred in 5 patients (16.7%) within 2 years, in 7 patients (23.3%) within 3 years, and in 12 patients (40%) within 5 years after the surgery. Over the 8-year study period, symptoms recurred in 13 patients (43.3%).
Repeated PBC is recommended for patients with recurrent trigeminal neuralgia after the first PBC or other unsuccessful treatments. Although the recurrence rate associated with the repeat PBC was slightly higher than that associated with the first, repeated PBC was safe, less complicated, and associated with a low incidence of dysesthesia and had a high success rate.
经皮球囊压迫术(PBC)是治疗卡马西平难治性三叉神经痛的一种替代手术方法。对于一些患者来说,PBC 是首选的治疗方法。然而,据我们所知,迄今为止尚未报道重复 PBC 的临床结果。
本研究旨在评估在 8 年的研究期间,对复发三叉神经痛患者进行重复 PBC 的结果和相关并发症发生率。
直到 2004 年 7 月,我们在我院对 272 例单侧三叉神经痛典型症状的患者进行了 PBC。43 例患者 PBC 成功,至少 3 个月无疼痛,但后来症状复发。在这 43 例患者中,32 例接受了重复(第二次)PBC,11 例接受了药物治疗。第二次 PBC 于 2001 年 3 月至 2004 年 12 月进行,患者随访至 2010 年 6 月。
32 例复发三叉神经痛患者参加了本研究。随访时间为 5.08 至 8.75 年(平均 6.43 年)。重复 PBC 后,30 例(93.8%)患者立即缓解神经痛。无患者出现短暂复视或感觉迟钝性疼痛。虽然有 2 例(6.2%)患者出现严重感觉减退,但可以耐受。6 例(18.8%)患者下颌活动受限。未观察到主要手术或麻醉并发症,也未死亡。手术后 3 个月内,无患者疼痛复发。5 例(16.7%)患者在 2 年内、7 例(23.3%)患者在 3 年内、12 例(40%)患者在 5 年内出现症状复发。在 8 年的研究期间,有 13 例(43.3%)患者症状复发。
对于第一次 PBC 或其他治疗失败后的复发三叉神经痛患者,建议重复 PBC。尽管重复 PBC 的复发率略高于第一次,但重复 PBC 安全、并发症少、感觉迟钝发生率低、成功率高。