氨基糖苷类耳毒性的机制及毛细胞保护靶点。
Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection.
作者信息
Huth M E, Ricci A J, Cheng A G
机构信息
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305-5739, USA.
出版信息
Int J Otolaryngol. 2011;2011:937861. doi: 10.1155/2011/937861. Epub 2011 Oct 25.
Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are reviewed in regard to established and potential future targets of hair cell protection.
氨基糖苷类药物是常用抗生素，对内耳有有害副作用。由于其强大的抗菌活性而被广泛应用，人们已做出许多努力来预防氨基糖苷类药物的耳毒性。多年来，对氨基糖苷类药物的抗菌机制和耳毒性机制的认识有所增加。现就已确立的和未来潜在的毛细胞保护靶点对这些机制进行综述。
Zotero 插件