Department of Clinical Immunology and Rheumatology, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands.
Atherosclerosis. 2012 Feb;220(2):425-8. doi: 10.1016/j.atherosclerosis.2011.10.040. Epub 2011 Nov 9.
Genetic variation in the gene ALOX5AP, encoding arachidonate 5-lipoxygenase-activating protein, have been suggested to increase risk for myocardial infarction and stroke. Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenesis of abdominal aortic aneurysm (AAA).
The association of the ALOX5AP haplotypes with AAA was assessed in a large population-based cohort of 613 men aged ≥65 years with screen-detected AAAs and 707 randomly selected age-matched controls without AAA. Taqman assays were used to assess seven previously described single nucleotide polymorphisms (SNPs) of ALOX5AP. Haplotypes A and B were defined by the four SNPs (SG13S25, SG13S114, SG13S89, SG13S32) and (SG13S377, SG13S114, SG13S41, SG13S35), respectively. After adjustment for cardiovascular risk factors, there were no significant differences in the distribution of ALOX5AP haplotypes between cases and controls.
A genetic predisposition to up-regulation of LT mediators is unlikely to play a dominant role in the pathogenesis of AAA.
编码花生四烯酸 5-脂氧合酶激活蛋白的基因 ALOX5AP 的遗传变异被认为会增加心肌梗死和中风的风险。来源于 5-脂氧合酶（5-LO）级联的白三烯（LTs）被认为与腹主动脉瘤（AAA）的发病机制有关。
在一项基于人群的大型队列研究中，评估了 ALOX5AP 单倍型与 AAA 的相关性。该队列纳入了 613 名年龄≥65 岁、经筛查发现的 AAA 男性患者和 707 名年龄匹配的无 AAA 对照组男性。使用 Taqman 测定法评估了 ALOX5AP 的七个先前描述的单核苷酸多态性（SNPs）。单倍型 A 和 B 由四个 SNPs（SG13S25、SG13S114、SG13S89、SG13S32）和（SG13S377、SG13S114、SG13S41、SG13S35）定义。在调整心血管危险因素后，病例组和对照组之间 ALOX5AP 单倍型的分布没有显著差异。
LT 介质上调的遗传易感性不太可能在 AAA 的发病机制中起主导作用。
