口腔恶性黑色素瘤。秘鲁人群的文献复习与经验。
Malignant melanoma of the oral cavity. Review of the literature and experience in a Peruvian Population.
机构信息
Av. Julio Bayletti 620, San Borja, Lima, Peru.
出版信息
Med Oral Patol Oral Cir Bucal. 2012 Mar 1;17(2):e206-11. doi: 10.4317/medoral.17477.
OBJECTIVE
To determine the epidemiological profile of malignant melanoma cases treated at the National Institute for Neoplastic Diseases "Dr. Eduardo Caceres Graziani" (INEN) over the period 1952 to 2008.
STUDY DESIGN
All clinical records with complete data of patients presenting a histopathological diagnosis of malignant melanoma of the oral cavity were reviewed. Data such as age, gender, location, tumor size, disease length, presence of metastasis, treatment received and year of admission were recorded.
RESULTS
During the study period 97 cases were found. The average age of patients was 52.85±1.6 years old mostly between 50 and 59 years old; the predominant gender was the female. The most common location was the palate and there was 58.8% of cases with a tumor size bigger than or equal to 4 cm. The length of the disease in 38.1% of the cases was longer than a year and in great part of the cases (69.1%) there was no metastasis. The treatment of choice was the surgery plus radiotherapy in 38.1% of the cases. According to the admission date it was also noted that the number of cases is increasing.
CONCLUSION
The results of this study demonstrate a late diagnosis and an increasing frequency of this neoplasia in the oral cavity.
目的
确定 1952 年至 2008 年期间在国家肿瘤疾病研究所“Eduardo Caceres Graziani 博士”（INEN）接受治疗的恶性黑色素瘤病例的流行病学特征。
研究设计
回顾了所有具有口腔恶性黑色素瘤组织病理学诊断完整数据的临床记录。记录了年龄、性别、位置、肿瘤大小、疾病长度、是否存在转移、接受的治疗以及入院年份等数据。
结果
在研究期间发现了 97 例病例。患者的平均年龄为 52.85±1.6 岁，多在 50 至 59 岁之间；性别以女性为主。最常见的部位是 palate，有 58.8%的病例肿瘤大小大于或等于 4cm。38.1%的病例疾病持续时间超过一年，大部分病例（69.1%）没有转移。首选治疗方法是手术加放疗，占 38.1%。根据入院日期，还注意到病例数量在增加。
结论
本研究结果表明口腔恶性黑色素瘤的诊断较晚，且发病率呈上升趋势。
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