瘦素抵抗不会引起大鼠的多食症。
Leptin resistance does not induce hyperphagia in the rat.
机构信息
Department of Integrative Physiology, University of Fukui, Matsuoka, Eiheiji-cho, Fukui, Japan.
出版信息
J Physiol Sci. 2012 Jan;62(1):45-51. doi: 10.1007/s12576-011-0184-5. Epub 2011 Dec 6.
Abstract
Leptin has been thought to work as a mediator for body weight control by inhibiting food intake. Leptin, however, cannot prevent obesity induced by a high-fat diet (HFD) probably because of leptin resistance. We investigated daily feeding and weight gain when ordinary chow (OC) was changed to a HFD in male rats. Food intake, by weight, significantly increased the next day, but gradually decreased until at 20 days the HFD intake contained the same calories as consumed by the OC-fed control rats. The reduction in food intake occurred only during the night without change of preference for the HFD, even after leptin resistance had developed. Nonetheless, the HFD-fed rats gained more weight than the controls. From the present experiment, it is concluded that leptin resistance does not induce hyperphagia, and suggested that body weight is not regulated to be constant.
摘要
瘦素被认为通过抑制食物摄入来作为体重控制的介质。然而，瘦素不能预防高脂肪饮食（HFD）引起的肥胖，可能是因为存在瘦素抵抗。我们研究了雄性大鼠普通饲料（OC）转换为 HFD 时的日常进食和体重增加情况。HFD 的摄入量在第二天按重量计显著增加，但逐渐减少，直到第 20 天，HFD 的摄入量与 OC 喂养的对照大鼠摄入的卡路里相同。这种食物摄入量的减少仅发生在夜间，而对 HFD 的偏好没有改变，即使在发生瘦素抵抗之后也是如此。尽管如此，HFD 喂养的大鼠比对照组体重增加更多。从本实验可以得出结论，瘦素抵抗不会引起多食，并且表明体重不受调节以保持恒定。
相似文献
1
Leptin resistance does not induce hyperphagia in the rat.
J Physiol Sci. 2012 Jan;62(1):45-51. doi: 10.1007/s12576-011-0184-5. Epub 2011 Dec 6.
2
Anorexic effects of intra-VTA leptin are similar in low-fat and high-fat-fed rats but attenuated in a subgroup of high-fat-fed obese rats.
Pharmacol Biochem Behav. 2013 Jan;103(3):573-81. doi: 10.1016/j.pbb.2012.10.012. Epub 2012 Oct 27.
3
Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity.
Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R773-80. doi: 10.1152/ajpregu.00727.2007. Epub 2008 Jul 2.
4
High-fat diet-induced changes in body mass and hypothalamic gene expression in wild-type and leptin-deficient mice.
Endocrine. 2008 Apr;33(2):176-88. doi: 10.1007/s12020-008-9070-1. Epub 2008 May 16.
5
Augmenting leptin circadian rhythm following a weight reduction in diet-induced obese rats: short- and long-term effects.
Metabolism. 2004 Jun;53(6):782-9. doi: 10.1016/j.metabol.2003.12.022.
6
Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.
Endocrinology. 2014 Jul;155(7):2411-22. doi: 10.1210/en.2013-1861. Epub 2014 Apr 17.
7
Determinants of high-fat diet hyperphagia: experimental dissection of orosensory and postingestive effects.
Am J Physiol. 1995 Jul;269(1 Pt 2):R30-7. doi: 10.1152/ajpregu.1995.269.1.R30.
8
The relation between dietary fructose, dietary fat and leptin responsiveness in rats.
Physiol Behav. 2011 Oct 24;104(5):914-22. doi: 10.1016/j.physbeh.2011.05.032. Epub 2011 Jun 13.
9
Controlling access time to a high-fat diet during the inactive period protects against obesity in mice.
Chronobiol Int. 2014 Oct;31(8):935-44. doi: 10.3109/07420528.2014.931413. Epub 2014 Jul 1.
10
Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors.
Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R55-63. doi: 10.1152/ajpregu.00002.2007. Epub 2007 Apr 4.
引用本文的文献
1
Modulation of the effects of a cholesterol-supplemented high-fat diet by aryl hydrocarbon receptor (AHR) activation and/or tryptophan reduction in male mice.
Toxicol Rep. 2025 Jul 7;15:102083. doi: 10.1016/j.toxrep.2025.102083. eCollection 2025 Dec.
2
Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats.
Int J Toxicol. 2023 Sep-Oct;42(5):407-419. doi: 10.1177/10915818231170527. Epub 2023 Apr 26.
3
Myristoylation of Src kinase mediates Src-induced and high-fat diet-accelerated prostate tumor progression in mice.
J Biol Chem. 2017 Nov 10;292(45):18422-18433. doi: 10.1074/jbc.M117.798827. Epub 2017 Sep 22.
4
High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice.
Biol Reprod. 2016 May;94(5):108. doi: 10.1095/biolreprod.115.137414. Epub 2016 Mar 30.
5
Trans and interesterified fat and palm oil during the pregnancy and lactation period inhibit the central anorexigenic action of insulin in adult male rat offspring.
J Physiol Sci. 2015 Jan;65(1):131-8. doi: 10.1007/s12576-014-0351-6. Epub 2014 Nov 15.
6
Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats.
J Physiol Sci. 2014 Mar;64(2):97-104. doi: 10.1007/s12576-013-0296-1. Epub 2013 Oct 27.
本文引用的文献
1
Decreased food intake following overfeeding involves leptin-dependent and leptin-independent mechanisms.
Physiol Behav. 2010 Jun 16;100(4):408-16. doi: 10.1016/j.physbeh.2010.04.006. Epub 2010 Apr 10.
2
Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats.
Neuropeptides. 2010 Feb;44(1):17-23. doi: 10.1016/j.npep.2009.11.005. Epub 2009 Dec 14.
3
An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat.
Physiol Behav. 2009 Jul 14;97(5):572-80. doi: 10.1016/j.physbeh.2009.02.010. Epub 2009 Feb 12.
4
Leptin resistance and the response to positive energy balance.
Physiol Behav. 2008 Aug 6;94(5):660-3. doi: 10.1016/j.physbeh.2008.04.009. Epub 2008 Apr 12.
5
Hypothalamic malonyl-coenzyme A and the control of energy balance.
Mol Endocrinol. 2008 Sep;22(9):2012-20. doi: 10.1210/me.2007-0538. Epub 2008 Mar 20.
6
Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.
Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R868-74. doi: 10.1152/ajpregu.00213.2006. Epub 2006 Oct 5.
7
Leptin regulation of the mesoaccumbens dopamine pathway.
Neuron. 2006 Sep 21;51(6):811-22. doi: 10.1016/j.neuron.2006.09.006.
8
Leptin receptor signaling in midbrain dopamine neurons regulates feeding.
Neuron. 2006 Sep 21;51(6):801-10. doi: 10.1016/j.neuron.2006.08.023.
9
Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats.
Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R148-54. doi: 10.1152/ajpregu.00041.2006. Epub 2006 Feb 16.
10
Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats.
Diabetologia. 2005 Jun;48(6):1075-83. doi: 10.1007/s00125-005-1763-x. Epub 2005 Apr 30.
Zotero 插件