氟西汀亚慢性处理减弱了 Aspidosperma ulei Markgr（夹竹桃科）的促勃起作用。
Subchronic treatment with fluoxetine attenuates the proerectile effect of Aspidosperma ulei Markgr (Apocyanaceae).
机构信息
Northeast Network on Biotechnology, Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Brazil.
出版信息
Indian J Pharmacol. 2011 Nov;43(6):707-9. doi: 10.4103/0253-7613.89831.
OBJECTIVE
To evaluate the ability of acute or chronic treatment with fluoxetine to alter the proerectile effect of Aspidosperma ulei alkaloid-rich fraction (F3-5).
MATERIALS AND METHODS
In the first series of experiments, three groups of mice received either a single intraperitoneal injection of vehicle, F3-5 (25 mg/kg) or fluoxetine (10 mg/kg) + F3-5. Three behavioral responses were counted over a period of 30 min: erection, erection-like response and genital grooming. In a second series of experiments, animals treated for 13 days with fluoxetine or fluoxetine + F3-5 were assessed.
RESULTS
A. ulei has been suggested to have proerectile effect in mice. Subchronic (13-d) treatment with fluoxetine resulted in a reduction in the number erections in F3-5-treated mice.
CONCLUSION
Sexual dysfunction associated with antidepressant treatment continues to be a major compliance issue for antidepressant therapy. Acute administration of fluoxetine resulted in a near total reversal of the proerectile effect of F3-5.
目的
评估氟西汀急性或慢性治疗对 Aspidosperma ulei 生物碱丰富部分（F3-5）促勃起作用的影响。
材料与方法
在第一组实验中，三组小鼠分别接受单次腹腔注射溶剂、F3-5（25mg/kg）或氟西汀（10mg/kg）+F3-5。在 30 分钟的时间内，记录三种行为反应：勃起、勃起样反应和生殖器梳理。在第二组实验中，评估接受氟西汀或氟西汀+F3-5 治疗 13 天的动物。
结果
A. ulei 被认为对小鼠有促勃起作用。氟西汀亚慢性（13 天）治疗导致 F3-5 治疗小鼠的勃起次数减少。
结论
与抗抑郁治疗相关的性功能障碍仍然是抗抑郁治疗的一个主要顺应性问题。氟西汀的急性给药几乎完全逆转了 F3-5 的促勃起作用。
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