番荔枝叶水提物可改善 5/6 肾切除大鼠的肾衰竭。
Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat.
机构信息
Department of Pharmacology, Nootan Pharmacy College, Visnagar- Gujarat, India.
出版信息
Indian J Pharmacol. 2011 Nov;43(6):718-21. doi: 10.4103/0253-7613.89834.
OBJECTIVE
To assess the renoprotective activity of the water extract of Annona squamosa in 5/6 nephrectomized animals.
MATERIALS AND METHODS
For evaluating the renoprotective effects of Annona squamosa, 5/6 nephrectomized rats were used as a model for renal failure. The effects of hot-water extract of leaves of Annona squamosa L. (A. squamosa) at a dose 300 mg/kg bw on biochemical and urinary parameters like plasma urea, plasma creatinine, and urine creatinine were analyzed. For elucidating its effect on oxidative stress, renal superoxide dismutase (SOD) levels were measured.
RESULTS
Nephrectomized rats (5/6) showed a significant rise in plasma urea and creatinine levels with a stable fall in urine creatinine. Treatment with A. squamosa extract (300 mg/kg bw) lead to a significant fall in the plasma urea and creatinine values with partial restoration to normal values along with a significant rise in the activity of SOD.
CONCLUSION
Thus, therapeutic strategies against oxidative stress could be effective in renal diseases. This study provides an indication to investigate further the efficacy of A. squamosa as a novel agent for alleviating renal failure.
目的
评估番荔枝水提取物在 5/6 肾切除动物中的肾保护活性。
材料和方法
为了评估番荔枝的肾保护作用，使用 5/6 肾切除大鼠作为肾衰竭模型。分析了番荔枝叶热水提取物（A. squamosa）剂量为 300mg/kg bw 时对生化和尿参数的影响，如血浆尿素、血浆肌酐和尿肌酐。为了阐明其对氧化应激的影响，测量了肾脏超氧化物歧化酶（SOD）水平。
结果
5/6 肾切除大鼠（5/6）的血浆尿素和肌酐水平显著升高，而尿肌酐水平稳定下降。用 A. squamosa 提取物（300mg/kg bw）治疗可显著降低血浆尿素和肌酐值，并部分恢复正常，同时 SOD 活性显著升高。
结论
因此，针对氧化应激的治疗策略可能对肾脏疾病有效。这项研究为进一步研究 A. squamosa 作为缓解肾衰竭的新型药物的功效提供了依据。
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