神经危重症监护病房中的免疫介导性疾病和免疫调节。
Immune mediated diseases and immune modulation in the neurocritical care unit.
机构信息
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
出版信息
Neurotherapeutics. 2012 Jan;9(1):99-123. doi: 10.1007/s13311-011-0096-3.
This chapter will review the spectrum of immune-mediated diseases that affect the nervous system and may result in an admission to the neurological intensive care unit. Immunomodulatory strategies to treat acute exacerbations of neurological diseases caused by aberrant immune responses are discussed, but strategies for long-term immunosuppression are not presented. The recommendations for therapeutic intervention are based on a synthesis of the literature, and include recommendations by the Cochrane Collaborative, the American Academy of Neurology, and other key organizations. References from recent publications are provided for the disorders and therapies in which randomized clinical trials and large evidenced-based reviews do not exist. The chapter concludes with a brief review of the mechanisms of action, dosing, and side effects of commonly used immunosuppressive strategies in the neurocritical care unit.
这一章将回顾影响神经系统的免疫介导性疾病谱，并可能导致患者入住神经重症监护病房。讨论了针对异常免疫反应引起的神经疾病急性加重的免疫调节治疗策略，但并未介绍长期免疫抑制策略。治疗干预建议是基于文献综合，包括 Cochrane 协作组织、美国神经病学学会和其他主要组织的建议。对于没有随机临床试验和大型循证综述的疾病和治疗方法，提供了来自近期出版物的参考文献。最后简要回顾了神经重症监护病房中常用免疫抑制策略的作用机制、剂量和副作用。
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