预防腹膜粘连：基因治疗的前景可期。
Prevention of peritoneal adhesions: a promising role for gene therapy.
出版信息
World J Gastroenterol. 2011 Dec 14;17(46):5049-58. doi: 10.3748/wjg.v17.i46.5049.
Abstract
Adhesions are the most frequent complication of abdominopelvic surgery, yet the extent of the problem, and its serious consequences, has not been adequately recognized. Adhesions evolved as a life-saving mechanism to limit the spread of intraperitoneal inflammatory conditions. Three different pathophysiological mechanisms can independently trigger adhesion formation. Mesothelial cell injury and loss during operations, tissue hypoxia and inflammation each promotes adhesion formation separately, and potentiate the effect of each other. Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation. This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions. It explores the promising role of combinatorial gene therapy and vector modifications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field.
摘要
粘连是腹盆腔手术最常见的并发症，但该问题的严重程度尚未得到充分认识。粘连是作为一种限制腹腔内炎症扩散的救命机制而产生的。有三种不同的病理生理机制可以独立触发粘连形成。手术过程中间皮细胞的损伤和丢失、组织缺氧和炎症都会分别促进粘连形成，并增强彼此的作用。研究反复表明，阻断单一途径并不能完全防止粘连形成。这篇综述总结了粘连形成的发病机制和单一基因治疗干预的结果。它探讨了组合基因治疗和载体修饰在预防粘连形成方面的有前途的作用，以激发新的思路，并鼓励该领域的快速发展。
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本文引用的文献
1
Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells.
Gene Ther. 2011 Mar;18(3):220-4. doi: 10.1038/gt.2010.123. Epub 2010 Oct 21.
2
Adhesion prevention and reduction: current status and future recommendations of a multinational interdisciplinary consensus conference.
Surg Innov. 2010 Sep;17(3):183-8. doi: 10.1177/1553350610379869.
3
Adhesion prevention in gynaecological surgery.
J Obstet Gynaecol Can. 2010 Jun;32(6):598-602. doi: 10.1016/S1701-2163(16)34530-3.
4
Connective tissue growth factor knockdown attenuated matrix protein production and vascular endothelial growth factor expression induced by transforming growth factor-beta1 in cultured human peritoneal mesothelial cells.
Ther Apher Dial. 2010 Feb;14(1):27-34. doi: 10.1111/j.1744-9987.2009.00701.x.
5
Intra-abdominal administration of bevacizumab diminishes intra-peritoneal adhesions.
Am J Surg. 2010 Aug;200(2):270-5. doi: 10.1016/j.amjsurg.2009.08.038. Epub 2010 Mar 15.
6
Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization.
J Immunol. 2010 Mar 1;184(5):2729-35. doi: 10.4049/jimmunol.0900215. Epub 2010 Jan 27.
7
The effect of CpG motifs on gene expression and clearance kinetics of aerosol administered polyethylenimine (PEI)-plasmid DNA complexes in the lung.
J Control Release. 2010 Apr 19;143(2):243-50. doi: 10.1016/j.jconrel.2010.01.003. Epub 2010 Jan 13.
8
Abdominal adhesions: current and novel therapies.
J Surg Res. 2011 Jan;165(1):91-111. doi: 10.1016/j.jss.2009.09.015. Epub 2009 Oct 2.
9
Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model.
Br J Surg. 2009 Nov;96(11):1323-35. doi: 10.1002/bjs.6722.
10
Nonviral gene delivery: principle, limitations, and recent progress.
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