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成功治疗严重血友病 A 患者的双重旁路手术:一例报告。

Successful double bypass in a patient with severe hemophilia A: a case report.

机构信息

Center for Hemorrhagic and Thrombotic Diseases, University Hospital of Udine, P.le S. Maria della Misericordia, 15, 33100, Udine, Italy.

出版信息

J Thromb Thrombolysis. 2012 Feb;33(2):193-6. doi: 10.1007/s11239-011-0664-8.

Abstract

Life expectancy in the hemophilia people is similar to the non-haemophilics and age-related cardiovascular disorders to become more prevalent, but cardiac surgery is considered a very high risk for these patients. In this article we report the successful cardiac double bypass internal mammary artery--coronary artery in a patient with severe hemophilia A. (FVIII<1%; missense mutation: exon 16, c.5508 G>A (domain A3), p.Trp1817Stop). Continuous infusion of rFVIII B-domain deleted was used to control haemostasis during surgery and in post-operative period. There was no bleeding complications and the patient did not need to receive transfusion of red blood cells or platelets.

摘要

血友病患者的预期寿命与非血友病患者相似,且与年龄相关的心血管疾病更为普遍,但心脏手术被认为对这些患者风险很高。本文报告了一名严重血友病 A 患者(FVIII<1%;错义突变:exon 16,c.5508 G>A(domain A3),p.Trp1817Stop)成功进行心脏双旁路内乳动脉-冠状动脉手术。在手术期间和术后,连续输注 rFVIII B 结构域缺失物以控制止血。没有出血并发症,患者也无需输注红细胞或血小板。

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