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德班印度人群冠心病的危险因素

Risk factors for coronary heart disease in the Indians of Durban.

作者信息

Seedat Y K, Mayet F G, Khan S, Somers S R, Joubert G

机构信息

Department of Medicine, University of Natal, Durban.

出版信息

S Afr Med J. 1990 Oct 20;78(8):447-54.

PMID:2218778
Abstract

Coronary heart disease (CHD) is a major problem in migrant Indians throughout the world. In South Africa it has reached 'epidemic' proportions. A field survey was conducted among Indians in the metropolitan area of Durban to determine the prevalence and known risk factors for CHD. In a study of 778 subjects aged 15-69 years (408 men), 15.3% (sex and age adjusted 13.4%) had a history of CHD. The important risk factors in men were hypercholesterolaemia, hypertriglyceridaemia, diabetes, and smoking, and in women diabetes, hypercholesterolaemia, and hypertriglyceridaemia. The minor risk factors were hyperuricaemia, sedentary occupation, obesity in women and a positive family history of CHD. A study of the major risk factors leading to CHD showed that 52% (sex and age adjusted 45.5%) had at least one major risk factor at the higher (level A) and 68% (sex and age adjusted 61.9%) at the lower (level B) risk levels. Diabetes mellitus was strongly associated with a positive history of CHD. In 47.6% (sex and age adjusted 48.2%) of the total group resting ECG abnormalities were found that could be coded. Because of the severe nature of CHD in the migrant Indian, an immediate and intensive programme of primary prevention of CHD risk factors should be instituted.

摘要

冠心病(CHD)是全球印度移民面临的一个主要问题。在南非,它已达到“流行”程度。在德班都会区的印度人群体中开展了一项实地调查,以确定冠心病的患病率和已知风险因素。在一项针对778名年龄在15 - 69岁的受试者(408名男性)的研究中,15.3%(经性别和年龄调整后为13.4%)有冠心病病史。男性的重要风险因素是高胆固醇血症、高甘油三酯血症、糖尿病和吸烟,女性的重要风险因素是糖尿病、高胆固醇血症和高甘油三酯血症。次要风险因素是高尿酸血症、久坐职业、女性肥胖以及冠心病家族史阳性。一项关于导致冠心病的主要风险因素的研究表明,在较高(A 级)风险水平下,52%(经性别和年龄调整后为45.5%)至少有一项主要风险因素;在较低(B 级)风险水平下,68%(经性别和年龄调整后为61.9%)至少有一项主要风险因素。糖尿病与冠心病阳性病史密切相关。在全部人群中,47.6%(经性别和年龄调整后为48.2%)被发现静息心电图异常且可编码。鉴于印度移民中冠心病的严重程度,应立即启动一项针对冠心病风险因素的初级预防强化计划。

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