Dzieciuchowicz Lukasz, Espinosa Gaudencio, Diaz Carmen Vigil, Lavilla Roya Francisco Javier, Lostao Javier Arbizu
Department of Angiology and Vascular Surgery, University Navarra, Pamplona, Spain.
Ann Vasc Surg. 2012 Apr;26(3):299-305. doi: 10.1016/j.avsg.2011.08.011. Epub 2011 Dec 20.
The purpose of this study was to analyze renal function in patients who underwent endovascular aneurysm repair with intentional occlusion of accessory renal artery (ARA).
A prospective study of six patients with abdominal aortic aneurysm who underwent an abdominal stentgraft implantation with intentional occlusion of at least one ARA was performed. The mean age of the patients was 71 (53-84) years. None of the patients had an estimated glomerular filtration rate (according to Modification of Diet in Renal Disease equation 4) lower than 60 mL/min/m(2). Before the intervention, a possible influence of the occlusion of ARA was assessed with a renal scintigraphy and percentage value of a renal mass at risk. After the intervention, a control renal scintigraphy was performed, and percentage value of lost renal mass was determined. Data on the renal function before the intervention and 1, 3, 10, 30, and 90 days after the intervention were collected.
There were no deaths, and none of the patients required hemodialysis in the follow-up period. In an early postoperative period, five patients had pain in the lumbar region that ceased with analgesics. An increase of the serum creatinine concentration occurred between 24 and 72 hours after the procedure and, except for 1 patient, started to decrease thereafter. After 30 and 90 days, all the patients presented serum creatinine concentrations similar to the basal values. The mean value of renal mass at risk was 18.5% (13.5-26%), and the mean value of lost renal mass was 18.4% (9.6-22.5%).
The endovascular aneurysm repair with an intentional occlusion of ARA is a safe therapeutic option of treatment of abdominal aortic aneurysm in the patients without preexisting renal disease. The renal scintigraphy seems to be useful in determining loss of functional renal mass.
本研究的目的是分析接受腹主动脉瘤腔内修复术并有意闭塞副肾动脉(ARA)的患者的肾功能。
对6例腹主动脉瘤患者进行前瞻性研究,这些患者接受了腹主动脉覆膜支架植入术并有意闭塞至少1条ARA。患者的平均年龄为71岁(53 - 84岁)。所有患者的估算肾小球滤过率(根据肾脏病饮食改良公式4)均不低于60 mL/(min·m²)。干预前,通过肾闪烁显像和有风险肾实质的百分比值评估ARA闭塞的可能影响。干预后,进行对照肾闪烁显像,并确定肾实质丢失的百分比值。收集干预前及干预后1、3、10、30和90天的肾功能数据。
随访期间无死亡病例,且无患者需要进行血液透析。术后早期,5例患者出现腰部疼痛,使用镇痛药后缓解。术后24至72小时血清肌酐浓度升高,除1例患者外,此后开始下降。30天和90天后,所有患者的血清肌酐浓度均与基础值相似。有风险肾实质的平均值为18.5%(13.5% - 26%),肾实质丢失的平均值为18.4%(9.6% - 22.5%)。
对于无基础肾脏疾病的患者,有意闭塞ARA的腹主动脉瘤腔内修复术是一种安全的腹主动脉瘤治疗选择。肾闪烁显像似乎有助于确定功能性肾实质的丢失。