阿试点研究营养状况的阿片类药物使用孕妇美沙酮维持治疗。
A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy.
机构信息
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Subst Use Misuse. 2012 Feb;47(3):286-95. doi: 10.3109/10826084.2011.635324.
Abstract
Pregnant women in methadone maintenance therapy may have poor nutrition during pregnancy. In 2006-2008, methadone-treated pregnant women (n = 22) were recruited at an urban academic medical center and compared with nondrug-using pregnant women (n = 119) at 20-35 weeks' gestation. We measured adiposity using prepregnancy body mass index (BMI), dietary intake using a food frequency questionnaire, and micronutrient and essential fatty acid status using biomarkers. Methadone-treated women had lower BMI, consumed more calories, had lower serum carotenoid concentrations, and higher plasma homocysteine concentrations than controls. The study's limitations and implications for future research are discussed.
摘要
美沙酮维持治疗的孕妇在孕期可能存在营养状况不良。2006-2008 年，我们在一家城市学术医疗中心招募了美沙酮治疗的孕妇（n=22），并与 20-35 孕周非吸毒孕妇（n=119）进行比较。我们使用孕前体重指数（BMI）测量肥胖程度，使用食物频率问卷测量饮食摄入，使用生物标志物测量微量营养素和必需脂肪酸状况。与对照组相比，美沙酮治疗的孕妇 BMI 较低，摄入的热量较多，血清类胡萝卜素浓度较低，血浆同型半胱氨酸浓度较高。讨论了研究的局限性和对未来研究的意义。
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