P(16)INK(4a) 的低甲基化：克什米尔山谷结直肠癌中的异常启动子甲基化及其相关性。
The blues of P(16)INK(4a): aberrant promoter methylation and association with colorectal cancer in the Kashmir valley.
机构信息
Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Kashmir 190011, India.
出版信息
Mol Med Rep. 2012 Apr;5(4):1053-7. doi: 10.3892/mmr.2012.740. Epub 2012 Jan 3.
Hypermethylation of the promoter region of the p16INK4a (p16) gene plays a significant role in the development and progression of colorectal cancer (CRC). The aim of the present study was to establish the role of the methylation status of the p16 gene in 114 CRC cases and to correlate it with the various clinicopathological parameters. Analysis of p16 promoter methylation was performed by methylation-specific PCR. Forty-eight (42.1%) of the CRC cases were found to be methylated for the p16 gene in our population. The methylation status was found to be associated with the gender, lymph node status, tumour stage, smoking status and tumour grade of the CRC patients. p16 plays a pivotal role in tumour development and progression to advanced stages.
抑癌基因 p16INK4a（p16）启动子区的异常高甲基化在结直肠癌（CRC）的发生发展中起着重要作用。本研究旨在建立 p16 基因甲基化状态在 114 例 CRC 病例中的作用，并将其与各种临床病理参数相关联。采用甲基化特异性 PCR 分析 p16 启动子甲基化。在我们的人群中，发现 48（42.1%）例 CRC 存在 p16 基因甲基化。甲基化状态与 CRC 患者的性别、淋巴结状态、肿瘤分期、吸烟状态和肿瘤分级有关。p16 在肿瘤的发生发展和向晚期进展中起着关键作用。
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