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[与长期使用甲氧麻黄酮相关的精神障碍。病例报告]

[Psychotic disorders related with chronic use of mephedrone. Case report].

作者信息

Urban Małgorzata, Rudecki Tomasz, Wróblewski Dariusz, Rabe-Jabłońska Jolanta

机构信息

Klinika Zaburzeń Afektywnych i Psychotycznych UM w Łodzi.

出版信息

Psychiatr Pol. 2011 May-Jun;45(3):431-7.

Abstract

AIM

The aim of the study was to present the case of a patient with psychotic disorders, o most probably connected with persistent mephedrone use.

METHOD

The analysis of the clinical case and medical documentation.

RESULTS

The presented patient had used mephedrone regularly (few times a week) for four months. Because of delusions of reference, delusions of persecution, agitation and anxiety, she required psychiatric hospitalisation. During the first hospitalisation she denied using legal highs, she was diagnosed as having schizophrenia and treated with olanzapine. After discharge, she didn't stop to use legal highs and psychotic symptoms occurred once again. The patient needed another hospitalisation. Despite the fact that antipsychotic treatment wasn't administered, the symptoms resolved. Nevertheless, somnolence, apathy and social isolation were observed.

CONCLUSIONS

Recently legal highs are very popular, especially among adolescents and young adults. That is the reason why physicians have become more anxious because there is little information about their contents. In most of them, synthetic or botanical substances are included. In clinical practice not only somatic but also psychiatric complications connected with legal high use are observed. It is difficult to verify why this patient developed psychotic symptoms after recurrent intoxication. It is possible that she has an individual predisposition to develop psychosis. In this case, we have no information about previous features of ultra high risk state in this patient.

摘要

目的

本研究旨在介绍一例患有精神障碍的患者,极有可能与持续使用甲基苯丙胺有关。

方法

对临床病例和医疗记录进行分析。

结果

该患者每周数次规律使用甲基苯丙胺达四个月。因存在关系妄想、被害妄想、激越和焦虑,她需要住院接受精神科治疗。首次住院期间,她否认使用过新型毒品,被诊断为精神分裂症并接受奥氮平治疗。出院后,她并未停止使用新型毒品,精神症状再次出现。该患者需要再次住院。尽管未给予抗精神病药物治疗,症状仍得以缓解。然而,观察到患者出现嗜睡、淡漠和社交隔离。

结论

近来新型毒品非常流行,尤其是在青少年和青年人群中。这就是医生们更加焦虑的原因,因为关于其成分的信息很少。其中大多数含有合成或植物性物质。在临床实践中,不仅观察到与使用新型毒品相关的躯体并发症,还观察到精神科并发症。很难证实该患者在反复中毒后为何会出现精神症状。有可能她具有个体易患精神病的倾向。在此病例中,我们没有关于该患者既往超高风险状态特征的信息。

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