来自植物内生真菌拟青霉的三卡拉斯辛 C 和 D。

Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii.

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China.

出版信息

Fitoterapia. 2012 Apr;83(3):541-4. doi: 10.1016/j.fitote.2011.12.021. Epub 2012 Jan 8.

DOI:10.1016/j.fitote.2011.12.021

PMID:22245082

Abstract

Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins D (3), M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC₅₀ value 5.72 μM, whereas the EC₅₀ values for compounds 1, 2 and 4, 5 are more than 40 μM.

摘要

从传统药用植物三七（Panax notoginseng (BurK.) F.H.Chen）内生真菌拟青霉（Trichoderma gamsii）中分离得到两种新的细胞松弛素，即三卡素 C（1）和 D（2），以及已知的细胞松弛素 aspochalasins D（3）、M（4）和 P（5）。新化合物 1 和 2 的结构通过 NMR 和 HRESIMS 确定，通过分析偶合常数和 NOESY 相关确定其相对构型。化合物 3 表现出抑制活性，EC₅₀ 值为 5.72 μM，而化合物 1、2 和 4、5 的 EC₅₀ 值均大于 40 μM。