Gallwas Julia, Mortensen Uwe, Gaschler Rebecca, Ochsenkuehn Robert, Stepp Herbert, Friese Klaus, Dannecker Christian
Department of Obstetrics and Gynecology, Ludwig- Maximilians University, Munich, Germany.
Lasers Surg Med. 2012 Mar;44(3):245-8. doi: 10.1002/lsm.22001. Epub 2012 Jan 13.
To establish and validate an ex vivo human cervical tissue model for optical coherence tomography (OCT) studies with special emphasis on investigating time dependent structural changes of the epithelium.
Four hundred OCT images were taken from 80 unsuspicious and suspicious areas of 18 fresh conisation specimens immediately after resection (0 hour) and 1, 2, 3, and 4 hours, referred to as waiting times in the following, postoperatively and compared to the corresponding histology. For each 2D-OCT-image, a 1D-intensity profile was generated. The profiles were analyzed with respect to systematic differences which may result from different waiting times, employing discriminant analysis (DA).
The different waiting times do not appear to imply significant differences among the corresponding OCT-images as represented by the intensity profiles.
We conclude that the proposed cervical tissue model appears to be applicable for ex vivo OCT studies.
建立并验证一种用于光学相干断层扫描（OCT）研究的离体人体宫颈组织模型，特别着重于研究上皮组织随时间的结构变化。
从18个新鲜锥形切除标本的80个无异常和可疑区域在切除后立即（0小时）、术后1、2、3和4小时（以下称为等待时间）获取400张OCT图像，并与相应的组织学结果进行比较。对于每张二维OCT图像，生成一维强度轮廓。使用判别分析（DA）分析这些轮廓，以研究不同等待时间可能导致的系统差异。
如强度轮廓所示，不同的等待时间似乎并未在相应的OCT图像之间显示出显著差异。
我们得出结论，所提出的宫颈组织模型似乎适用于离体OCT研究。
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