使用体内模型评估决明的抗糖尿病潜力。
Assessment of the antidiabetic potential of Cassia grandis using an in vivo model.
作者信息
Lodha Sandesh R, Joshi Shrikant V, Vyas Bhavin A, Upadhye Mohini C, Kirve Megha S, Salunke Shweta S, Kadu Sheetal K, Rogye Manasi V
机构信息
Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat, India.
出版信息
J Adv Pharm Technol Res. 2010 Jul;1(3):330-3. doi: 10.4103/0110-5558.72429.
The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.
通过葡萄糖耐量试验，在正常大鼠和四氧嘧啶诱导的糖尿病大鼠中，对决明属植物（豆科）的水提取物和乙醇提取物的抗糖尿病活性进行了评估。水提取物和乙醇提取物在葡萄糖耐量试验中均显示出能显著将血糖水平降至正常。在四氧嘧啶诱导的糖尿病大鼠中，在体重剂量为150mg/kg时，三小时后观察到血糖的最大降幅。水提取物和乙醇提取物的保护百分比分别为32.72%和46.42%。在对四氧嘧啶诱导的糖尿病大鼠的长期治疗中，通过在第十天测量血糖、胆固醇和甘油三酯来确定保护程度。两种提取物均显示出与格列本脲相当的显著抗糖尿病活性。这些结果表明决明属植物具有显著的抗糖尿病活性。
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