School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Molecules. 2012 Jan 17;17(1):843-50. doi: 10.3390/molecules17010843.
An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).
研究了酸模根的乙酸乙酯提取物。通过光谱数据鉴定了三种化合物，分别为大黄酚（1）、6-甲基-7-乙酰基-1,8-二羟基-3-甲氧基萘-1-O-β-D（L）-葡萄糖苷（2）和 6-甲基-7-乙酰基-1,8-二羟基萘-1-O-β-D（L）-葡萄糖苷（3）。化合物 2 和 3 是新化合物。通过 MTT 法在四种细胞系（乳腺癌 MCF-7、胃癌 7901、黑色素瘤 A375 和卵巢癌 SKOV-3）中测试了它们的增殖活性。
