分枝杆菌副结核亚种和 Epstein-Barr 病毒是否是撒丁岛多发性硬化症的触发因素？
Are Mycobacterium avium subsp. paratuberculosis and Epstein-Barr virus triggers of multiple sclerosis in Sardinia?
机构信息
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Università di Sassari, Italy.
出版信息
Mult Scler. 2012 Aug;18(8):1181-4. doi: 10.1177/1352458511433430. Epub 2012 Jan 19.
Sardinia acts as an ideal setting for multiple sclerosis (MS) studies because its prevalence of MS is one of the highest worldwide. Several pathogens have been investigated amongst 119 Sardinian MS patients and 117 healthy controls to determine whether they might have a role in triggering MS in genetically predisposed individuals. Mycobacterium avium subsp. paratuberculosis (MAP) and Epstein Barr virus DNA were detected in 27.5% and 17.3%, respectively, of the MS patients. Moreover an extremely high humoral immune response against MAP recombinant protein MAP FprB (homologous to human myelin P0) was observed, whereas no significant results were found against Mycobacterium tuberculosis FprA and Helicobacter pylori HP986 protein.
撒丁岛是多发性硬化症（MS）研究的理想场所，因为其 MS 患病率是世界上最高的之一。在 119 名撒丁岛多发性硬化症患者和 117 名健康对照者中，研究了 11 种病原体，以确定它们是否可能在遗传易感性个体中引发 MS。分枝杆菌副结核亚种（MAP）和 Epstein Barr 病毒 DNA 分别在 27.5%和 17.3%的 MS 患者中被检测到。此外，对 MAP 重组蛋白 MAP FprB（与人髓鞘 P0 同源）表现出极高的体液免疫反应，而对结核分枝杆菌 FprA 和幽门螺杆菌 HP986 蛋白则未发现显著结果。
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