Jas Biologicals Ltd, 12 Pembroke Avenue, Denny Industrial Estate, Waterbeach, Cambridge CB25 9QR, UK.
Vaccine. 2012 Feb 27;30(10):1767-81. doi: 10.1016/j.vaccine.2012.01.014. Epub 2012 Jan 17.
This paper offers an overview of important veterinary viral diseases of mammals stemming from aberrant immune response. Diseases reviewed comprise those due to lentiviruses of equine infectious anaemia, visna/maedi and caprine arthritis encephalitis and feline immunodeficiency. Diseases caused by viruses of feline infectious peritonitis, feline leukaemia, canine distemper and aquatic counterparts, Aleutian disease and malignant catarrhal fever. We also consider prospects of immunoprophylaxis for the diseases and briefly other control measures. It should be realised that the outlook for effective vaccines for many of the diseases is remote. This paper describes the current status of vaccine research and the difficulties encountered during their development.
本文概述了源于异常免疫反应的重要哺乳动物兽医病毒病。综述的疾病包括马传染性贫血、维斯纳/梅迪和山羊关节炎脑炎和猫免疫缺陷病毒引起的疾病。还考虑了猫传染性腹膜炎、猫白血病、犬瘟热和水生动物对应的疾病、阿留申病和恶性卡他热的病毒引起的疾病。我们还考虑了针对这些疾病的免疫预防的前景,并简要介绍了其他控制措施。应该认识到,许多疾病的有效疫苗的前景是遥远的。本文描述了疫苗研究的现状和在其开发过程中遇到的困难。