新型半合成多肽西洛芬净（LY121019）对曲霉属和念珠菌属的体外活性
In vitro activity of the new semi-synthetic polypeptide cilofungin (LY121019) against Aspergillus and Candida species.
作者信息
Huang A, Edwards F, Bernard E M, Armstrong D, Schmitt H J
机构信息
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
出版信息
Eur J Clin Microbiol Infect Dis. 1990 Sep;9(9):697-9. doi: 10.1007/BF01964276.
The in vitro activity of cilofungin (LY121019), a new semi-synthetic antifungal agent was evaluated. Potent activity was seen against Candida albicans and Candida tropicalis, with almost identical MIC and MFC results, whereas no activity was seen against any isolates of Candida parapsilosis or three Aspergillus spp. However, MICs were dependent on medium and test conditions chosen. It is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in vitro activity depends on the method used.
对一种新型半合成抗真菌药物西洛芬净（LY121019）的体外活性进行了评估。观察到其对白色念珠菌和热带念珠菌具有强效活性，最小抑菌浓度（MIC）和最小杀菌浓度（MFC）结果几乎相同，而对近平滑念珠菌的任何分离株或三种曲霉菌均无活性。然而，MICs取决于所选择的培养基和测试条件。得出的结论是，西洛芬净在体外对一些具有重要医学意义的酵母菌具有良好活性，且其体外活性取决于所使用的方法。
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