G 蛋白偶联受体介导的突触传递调节。
GPCR mediated regulation of synaptic transmission.
机构信息
Vanderbilt University Medical Center, 442 Robinson Research Building, 23rd Ave. South @ Pierce, Nashville, TN 37232-6600, USA.
出版信息
Prog Neurobiol. 2012 Mar;96(3):304-21. doi: 10.1016/j.pneurobio.2012.01.009. Epub 2012 Jan 28.
Abstract
Synaptic transmission is a finely regulated mechanism of neuronal communication. The release of neurotransmitter at the synapse is not only the reflection of membrane depolarization events, but rather, is the summation of interactions between ion channels, G protein coupled receptors, second messengers, and the exocytotic machinery itself which exposes the components within a synaptic vesicle to the synaptic cleft. The focus of this review is to explore the role of G protein signaling as it relates to neurotransmission, as well as to discuss the recently determined inhibitory mechanism of Gβγ dimers acting directly on the exocytotic machinery proteins to inhibit neurotransmitter release.
摘要
突触传递是神经元通讯的一种精细调节机制。神经递质在突触中的释放不仅是膜去极化事件的反映，而是离子通道、G 蛋白偶联受体、第二信使以及胞吐机制本身之间相互作用的总和，这些相互作用将突触小泡内的成分暴露在突触间隙中。本综述的重点是探讨 G 蛋白信号转导与神经传递的关系，并讨论最近确定的 Gβγ 二聚体直接作用于胞吐机制蛋白抑制神经递质释放的抑制机制。
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本文引用的文献
1
Label-free detection of G protein-SNARE interactions and screening for small molecule modulators.
ACS Chem Neurosci. 2012 Jan 18;3(1):69-78. doi: 10.1021/cn200102d.
2
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Cell. 2011 Oct 28;147(3):666-77. doi: 10.1016/j.cell.2011.09.046.
3
In vivo analysis of conserved C. elegans tomosyn domains.
PLoS One. 2011;6(10):e26185. doi: 10.1371/journal.pone.0026185. Epub 2011 Oct 14.
4
Complexin cross-links prefusion SNAREs into a zigzag array.
Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101.
5
Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.
PLoS One. 2011;6(5):e20500. doi: 10.1371/journal.pone.0020500. Epub 2011 May 25.
6
Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor.
Neuron. 2011 Feb 24;69(4):736-48. doi: 10.1016/j.neuron.2011.01.013.
7
Multiple targets of μ-opioid receptor-mediated presynaptic inhibition at primary afferent Aδ- and C-fibers.
J Neurosci. 2011 Jan 26;31(4):1313-22. doi: 10.1523/JNEUROSCI.4060-10.2011.
8
Complexin maintains vesicles in the primed state in C. elegans.
Curr Biol. 2011 Jan 25;21(2):106-13. doi: 10.1016/j.cub.2010.12.015. Epub 2011 Jan 6.
9
Chaperoning the SNAREs: a role in preventing neurodegeneration?
Nat Cell Biol. 2011 Jan;13(1):8-9. doi: 10.1038/ncb0111-8.
10
Etomidate and propofol inhibit the neurotransmitter release machinery at different sites.
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