手术切除联合术后即刻辅助放疗治疗瘢痕疙瘩的临床疗效
[Clinical efficacy of keloids treated by surgical ablation and immediate postoperative adjuvant radiotherapy].
作者信息
Li Peng-cheng, Jia Chi-yu, Li Yue-min, Nie Kai-yu, Chi Ying-chun, Hu Guo-dong, Qiu Ya-bin, Liu Zhen
机构信息
Department of Burns & Plastic Surgery, No. 309 Chinese PLA Hospital, Beijing, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2011 Dec 6;91(45):3223-4.
OBJECTIVE
To evaluate the clinical efficacy of intralesional excision and immediate postoperative adjuvant radiotherapy in the treatment of keloids.
METHODS
Eighty-one patients with a combined total of 86 keloids were treated with 6 MeV electron beam radiotherapy after surgical intralesional excision of keloids. All received a total dose of 15 - 20 Gy for 5 consecutive days beginning the day of surgery. The time interval between keloid excision and the delivery of first fraction of radiotherapy was < 6 h. The post-operative follow-up period was 12 - 31 months.
RESULTS
Forty-three cases yielded excellent outcomes and there were 18 fair cases. The overall effective rate was 85.9%. There were 10 recurrent cases. Only adverse effects such as delayed wound-healing and telangiectasias (11.3%) were found. Neither severe complications nor secondary malignancies occurred.
CONCLUSION
Intralesional excision of keloid and postoperative electron radiotherapy are well-tolerated and efficacious in the prevention of keloid recurrence.
目的
评估瘢痕疙瘩病损内切除及术后即刻辅助放疗的临床疗效。
方法
81例患者共86个瘢痕疙瘩，在瘢痕疙瘩病损内手术切除后接受6 MeV电子束放疗。均于手术当日起连续5天接受总剂量15 - 20 Gy的放疗。瘢痕疙瘩切除与首次放疗之间的时间间隔<6小时。术后随访期为12 - 31个月。
结果
43例效果极佳，18例效果尚可。总有效率为85.9%。有10例复发。仅发现如伤口愈合延迟和毛细血管扩张（11.3%）等不良反应。未发生严重并发症及继发性恶性肿瘤。
结论
瘢痕疙瘩病损内切除及术后电子放疗耐受性良好，对预防瘢痕疙瘩复发有效。
Zotero 插件