[三维适形放疗联合经动脉化疗栓塞及手术干预治疗肝细胞癌合并门静脉癌栓]
[Combined three-dimensional conformal radiotherapy plus transcatheter arterial chemoembolization and surgical intervention for portal vein tumor thrombus in patients with hepatocellular carcinoma].
作者信息
Wu Zhi-jun, Cai Jing, Xu Ai-bing, Su Xiao-qin, Wang Xiang-qian, Zhang Yi-xin, Shao Bing-feng, Li Yong-jun, Chu Kai-yue
机构信息
Nantong Tumor Hospital, Nantong 226361, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2011 Nov 1;91(40):2841-4.
OBJECTIVE
To explore the clinical therapeutic efficacies of combined three-dimensional conformal radiotherapy (3DCRT) plus transcatheter arterial chemoembolization (TACE) for portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC).
METHODS
A total of 145 HCC patients with tumor thrombus in portal vein were divided randomly into 2 groups. Group A (n = 64) was treated with surgical intervention alone while group B (n = 81) underwent 3DCRT plus TACE. The gross tumor volume (GTV) was defined as PVTT only.
RESULTS
Survival rates of group A at year 1 and 2 were 40.3% and 21.9% with a mean survival time (MST) of 15.2 months while that of group B were 41.2% and 22.5% with a MST of 15.8 months. The total effective rates of groups A and B was 40.6% (28/64) and 44.4% (36/81) respectively.
CONCLUSION
The therapeutic efficacy of 3DCRT plus TACE is similar to that of surgical intervention.
目的
探讨三维适形放疗（3DCRT）联合经动脉化疗栓塞术（TACE）治疗肝细胞癌（HCC）门静脉癌栓（PVTT）的临床疗效。
方法
将145例伴有门静脉癌栓的HCC患者随机分为两组。A组（n = 64）单纯接受手术干预，而B组（n = 81）接受3DCRT联合TACE治疗。肿瘤总体积（GTV）仅定义为门静脉癌栓。
结果
A组1年和2年生存率分别为40.3%和21.9%，平均生存时间（MST）为15.2个月；而B组分别为41.2%和22.5%，MST为15.8个月。A组和B组的总有效率分别为40.6%（28/64）和44.4%（36/81）。
结论
3DCRT联合TACE的治疗效果与手术干预相似。
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