Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA.
J Thorac Cardiovasc Surg. 2012 Apr;143(4):854-63. doi: 10.1016/j.jtcvs.2011.12.048. Epub 2012 Feb 15.
Recent trials comparing on-pump (CABG) with off-pump coronary artery bypass grafting (OPCAB) have been criticized by those who believe that surgeon inexperience may explain the apparent worse outcomes for OPCAB. However, the true effect of surgeon volume on outcomes after OPCAB remains unknown. The purpose of this study was to examine the effect of surgeon volume on risk-adjusted mortality after OPCAB.
From 2003 to 2007, 709,483 patients underwent coronary artery bypass grafting operations (CABG = 439,253; OPCAB = 270,230) within the Nationwide Inpatient Sample database. Hierarchic generalized linear regression modeling with spline functions for annual individual operating surgeon volume was used to assess the relationship between annual surgeon volume and inpatient mortality, adjusted for comorbid disease and other potential confounders.
OPCAB was performed in 38.1% of coronary artery bypass grafting operations. The average age for those undergoing OPCAB was 66.1 ± 11.1 years, and female patients accounted for 29.3% of operations with 1-vessel (20.4%), 2-vessel (36.6%), 3-vessel (20.5%), or 4 vessels or more (13.6%). Median surgeon volume for OPCAB was 105 (56-156) operations per year. A highly significant nonlinear relationship between surgeon volume and risk-adjusted mortality was observed for OPCAB operations (P < .01). Specifically, an estimated 5% decrease in the absolute probability of death occurred after OPCAB performed by the surgeons with the highest volume, which is greater than the 3% estimated decrease for conventional CABG. Of note, the effect of surgeon volume on mortality was significantly less than other risk factors, such as the presence of heart failure, renal failure, type of bypass conduit, and gender.
A significant surgeon volume-outcome relationship exists for mortality after OPCAB with a threshold of more than 50 operations per year. However, the contribution of surgeon volume to the probability of death is incrementally small compared with other patient and operative characteristics. This demonstrates that outcomes after OPCAB are more dependent on patient risk factors than on surgeon volume.
最近比较体外循环(CABG)与非体外循环冠状动脉旁路移植术(OPCAB)的临床试验受到了质疑,质疑者认为外科医生经验不足可能解释了 OPCAB 术后明显较差的结果。然而,外科医生手术量对 OPCAB 术后结果的真正影响仍不清楚。本研究旨在探讨外科医生手术量对 OPCAB 后风险调整死亡率的影响。
2003 年至 2007 年,全国住院患者样本数据库中 709483 例患者接受冠状动脉旁路移植术(CABG=439253 例;OPCAB=270230 例)。采用带有样条函数的层次广义线性回归模型对年度个体手术医生手术量进行评估,调整合并症和其他潜在混杂因素后,分析年度外科医生手术量与住院死亡率之间的关系。
OPCAB 占冠状动脉旁路移植术的 38.1%。行 OPCAB 的患者平均年龄为 66.1±11.1 岁,女性患者占手术患者的 29.3%,1 支血管病变(20.4%)、2 支血管病变(36.6%)、3 支血管病变(20.5%)或 4 支或更多血管病变(13.6%)。OPCAB 的中位外科医生手术量为每年 105(56-156)例。观察到 OPCAB 手术中外科医生手术量与风险调整死亡率之间存在高度显著的非线性关系(P<0.01)。具体来说,与常规 CABG 相比,由手术量最高的外科医生进行的 OPCAB 术后死亡绝对概率估计降低了 5%,而常规 CABG 术后死亡绝对概率估计降低了 3%。值得注意的是,外科医生手术量对死亡率的影响明显小于心力衰竭、肾衰竭、旁路移植管类型和性别等其他危险因素。
OPCAB 术后死亡率与外科医生手术量之间存在显著的关系,阈值超过每年 50 例。然而,与其他患者和手术特征相比,外科医生手术量对死亡概率的贡献逐渐较小。这表明 OPCAB 术后的结果更多地取决于患者的风险因素,而不是外科医生的手术量。