Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
J Womens Health (Larchmt). 2012 Jun;21(6):628-33. doi: 10.1089/jwh.2011.3318. Epub 2012 Mar 2.
It is recognized that a history of gestational diabetes mellitus (GDM) predicts incident type 2 diabetes in women. However, it is unclear if there is a racial disparity between the association of GDM and type 2 diabetes.
We studied 1,142 women with a history of GDM and 18,856 women without a history of GDM aged 13-50 years with their first record of pregnancy in Louisiana State University Hospital-Based Longitudinal Study database between 1990 and 2009. History of GDM was used to predict incident type 2 diabetes.
During a mean follow-up of 8.6 years, 1,394 women developed type 2 diabetes. The multivariable adjusted hazard ratio (HR) of type 2 diabetes was 6.52 (95% confidence interval [CI] 5.73-7.43) among women with GDM compared to women without GDM. Stratification by age, race, and body mass index (BMI) gave similar results. Compared with African American and white women without a history of GDM, the relative risk for type 2 diabetes was higher in African American women than in white women with a history of GDM. Compared with non-GDM women compartments, GDM women after delivery for <1, 1.0-3.9, 4.0-5.9, 6.0-7.9, 8-9.9, and ≥10.0 years had 4.00, 5.44, 4.26, 3.16, 4.49, and 4.17 times higher risk of having type 2 diabetes, respectively.
A history of GDM is a strong predictor of subsequent type 2 diabetes among Louisiana women, especially among African American women.
人们认识到，妊娠糖尿病史（GDM）可预测女性 2 型糖尿病的发生。然而，GDM 与 2 型糖尿病之间的关联是否存在种族差异尚不清楚。
我们研究了 1142 名患有 GDM 病史和 18856 名无 GDM 病史的女性，她们于 1990 年至 2009 年在路易斯安那州立大学医院队列研究数据库中首次怀孕。GDM 病史用于预测 2 型糖尿病的发生。
在平均 8.6 年的随访期间，有 1394 名女性发生 2 型糖尿病。与无 GDM 病史的女性相比，患有 GDM 的女性发生 2 型糖尿病的多变量调整后的危险比（HR）为 6.52（95%置信区间[CI] 5.73-7.43）。按年龄、种族和体重指数（BMI）分层也得出了类似的结果。与非 GDM 病史的非裔美国人和白人女性相比，有 GDM 病史的非裔美国女性发生 2 型糖尿病的相对风险高于白人女性。与非 GDM 女性相比，分娩后 GDM 女性 <1 年、1.0-3.9 年、4.0-5.9 年、6.0-7.9 年、8.0-9.9 年和≥10.0 年发生 2 型糖尿病的风险分别高出 4.00、5.44、4.26、3.16、4.49 和 4.17 倍。
在路易斯安那州女性中，GDM 病史是发生 2 型糖尿病的一个强有力的预测因素，尤其是在非裔美国女性中。
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