Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, USA.
Aging Dis. 2011 Dec;2(6):512-23. Epub 2011 Dec 2.
The deterioration of immune function with advancing age is associated with an increased incidence of cancer. Most of the studies to evaluate the effect of immunotherapy on cancer have been conducted in the young without considering the effect of age-associated changes in immune function. Studies from my laboratory and others groups indicate that immunotherapeutic interventions could be effective in young animals, but that the same therapies are not as effective in old animals. The present review summarizes some defects found in the old immune system affecting the activation of antitumor immune responses, the strategies used to activate a more robust antitumor immune response in the old and the description of a preclinical tumor model indicating possible strategies for optimization of immunotherapeutic interventions in the old.
随着年龄的增长，免疫功能的衰退与癌症发病率的增加有关。大多数评估免疫疗法对癌症影响的研究都是在年轻人中进行的，没有考虑到与年龄相关的免疫功能变化的影响。我的实验室和其他研究小组的研究表明，免疫治疗干预在年轻动物中可能是有效的，但在老年动物中，同样的疗法效果并不那么显著。本综述总结了一些在衰老免疫系统中发现的缺陷，这些缺陷影响了抗肿瘤免疫反应的激活，以及在老年中激活更强大的抗肿瘤免疫反应所使用的策略，并描述了一个临床前肿瘤模型，该模型为优化老年免疫治疗干预提供了可能的策略。
