抗肿瘤药。587. 从水仙品种冰美人中分离和结构鉴定 3-表长春质碱。
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
机构信息
Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, PO Box 871604, Tempe, Arizona 85287-1604, USA.
出版信息
J Nat Prod. 2012 Apr 27;75(4):771-3. doi: 10.1021/np200862y. Epub 2012 Mar 13.
Bioassay-guided (cancer cell line) separation of an extract prepared from Narcissus cv. Ice Follies (from The Netherlands) led to the isolation of a new Amaryllidaceae isocarbostiryl, 3-epipancratistatin (1b), as well as narciclasine (2). This Narcissus cultivar was found to be a good source of narciclasine. The structure of 1b was established by high-resolution mass and high-field 2D NMR spectroscopic analyses. Against a panel of murine and human cancer cell lines, 3-epipancratistatin (1b) led to cell growth inhibition (GI(50) 2.2-0.69 μg/mL) some 100× less than that found for pancratistatin (1a) and narciclasine (2), thereby revealing an important configurational requirement in 1a for strong cancer cell growth inhibition.
经生物测定指导（癌细胞系）分离，从荷兰产的冰美人水仙中提取出一种新的石蒜科异卡波肼，3-表阿朴潘克拉辛（1b），以及水仙碱（2）。这种水仙品种被发现是水仙碱的良好来源。通过高分辨率质谱和高场二维 NMR 光谱分析确定了 1b 的结构。对一系列鼠类和人类癌细胞系的检测显示，3-表阿朴潘克拉辛（1b）的细胞生长抑制作用（GI50 为 2.2-0.69μg/mL）比潘克拉辛（1a）和水仙碱（2）低约 100 倍，这表明 1a 中存在一个重要的结构要求，以强烈抑制癌细胞生长。
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