胃癌与 TBX21 基因-1993 多态性的相关性。
Association between gastric cancer and -1993 polymorphism of TBX21 gene.
机构信息
Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China.
出版信息
World J Gastroenterol. 2012 Mar 14;18(10):1117-22. doi: 10.3748/wjg.v18.i10.1117.
AIM
To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population.
METHODS
The -1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age, sex and ethnicity.
RESULTS
Compared with the TBX21 -1993TT genotype, the -1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio (OR) = 3.42, 95% confidence interval (CI): 1.41-8.31]. The relationship between the -1993 polymorphic genotype and the invasive status such as lymph node and distant metastasis was found among the gastric cancer patients (OR = 4.02, 95% CI: 1.87-8.66; OR = 7.02, 95% CI: 3.44-14.34, respectively).
CONCLUSION
TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
目的
探讨中国人 TBX21 基因多态性与胃癌风险的关系。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法鉴定 TBX21 基因启动子区-1993 位多态性。通过多元逻辑回归分析，在 220 例胃癌患者和 262 例年龄、性别和种族匹配的无癌对照中，确定 TBX21 基因基因型与胃癌的风险关系。
结果
与 TBX21-1993TT 基因型相比，-1993CC 基因型患胃癌的风险显著升高[比值比（OR）=3.42，95%置信区间（CI）：1.41-8.31]。在胃癌患者中发现，-1993 多态性基因型与淋巴结和远处转移等侵袭状态之间存在关系（OR=4.02，95%CI：1.87-8.66；OR=7.02，95%CI：3.44-14.34）。
结论
TBX21-1993 多态性可能导致胃癌的发生风险增加，特别是远处转移。
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