5α-还原酶抑制剂在调节吗啡镇痛作用中的作用：疼痛管理中的一个新兴概念。 - Suppr

Role of 5α-reductase inhibitors in modulation of the analgesic effects of morphine: an emerging concept in pain management.

作者信息

Kapoor Shailendra

出版信息

Neurol Sci. 2013 Apr;34(4):577. doi: 10.1007/s10072-012-1016-y. Epub 2012 Mar 17.

DOI:10.1007/s10072-012-1016-y

PMID:22426788

Abstract

摘要

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Role of 5α-reductase inhibitors in modulation of the analgesic effects of morphine: an emerging concept in pain management.

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Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats.

Pharmacol Biochem Behav. 2011 Mar;98(1):62-6. doi: 10.1016/j.pbb.2010.12.016. Epub 2010 Dec 22.

Anti-nociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals.

Eur J Drug Metab Pharmacokinet. 2008 Jul-Sep;33(3):181-6. doi: 10.1007/BF03191116.

Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat.

Horm Behav. 2007 May;51(5):605-10. doi: 10.1016/j.yhbeh.2007.02.008. Epub 2007 Mar 2.

In vivo evidence for an increase in 5alpha-reductase activity in the rat central nervous system following morphine exposure.

Int J Dev Neurosci. 2005 Nov;23(7):621-6. doi: 10.1016/j.ijdevneu.2005.07.001. Epub 2005 Sep 6.

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Role of 5α-reductase inhibitors in modulation of the analgesic effects of morphine: an emerging concept in pain management.

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