微小 RNA，NF-κB 的新效应因子和调节因子。

MicroRNAs, new effectors and regulators of NF-κB.

机构信息

Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.

出版信息

Immunol Rev. 2012 Mar;246(1):205-20. doi: 10.1111/j.1600-065X.2011.01089.x.

DOI:10.1111/j.1600-065X.2011.01089.x

Abstract

Since its discovery 25 years ago, nuclear factor-κB (NF-κB) has emerged as a transcription factor that controls diverse biological functions, ranging from inflammation to learning and memory. Activation of NF-κB initiates an elaborate genetic program. Some of the NF-κB-driven genes do not encode proteins but rather are precursors to microRNAs. These microRNAs play important roles in the regulation of the inflammatory process, some being inhibitory and others activating. Here, we discuss both the regulation of their expression and the function of some of these non-coding RNA genes. We also include a personal discussion of how NF-κB was first discovered.

摘要

自 25 年前被发现以来，核因子-κB（NF-κB）已成为一种转录因子，控制着从炎症到学习和记忆等多种生物学功能。NF-κB 的激活会启动一个复杂的遗传程序。一些 NF-κB 驱动的基因不编码蛋白质，而是 microRNAs 的前体。这些 microRNAs 在炎症过程的调节中发挥着重要作用，有些是抑制性的，有些是激活性的。在这里，我们讨论了它们表达的调节以及其中一些非编码 RNA 基因的功能。我们还包括了个人讨论，介绍了 NF-κB 是如何首次被发现的。