用于预防血栓形成的阿司匹林预防：期望与局限性。
Aspirin prophylaxis for the prevention of thrombosis: expectations and limitations.
作者信息
Rao Gundu H R, Fareed Jawad
机构信息
Lillehei Heart Institute, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
出版信息
Thrombosis. 2012;2012:104707. doi: 10.1155/2012/104707. Epub 2012 Feb 7.
Platelets play a very important role in the pathogenesis of acute vascular events leading to thrombosis of the coronary and cerebral arteries. Blockage of these arteries leading to regional ischemia of heart and brain tissues precipitate heart attacks and stroke. Acetyl salicylic acid (Aspirin) has been the drug of choice for over half a century for the primary and secondary prophylaxis of thrombotic events. In spite of its extensive use as an antiplatelet drug for the prevention of vascular thrombosis, there is considerable concern about the degree of protection it offers, to patients under aspirin therapy. In this paper, we explain the phenomenon of aspirin resistance, discuss the limitations of aspirin therapy, and suggest methods to monitor "at-risk" individuals. Ability to monitor and determine at risk patients will provide opportunities for the clinicians to customize antiplatelet therapies.
血小板在导致冠状动脉和脑动脉血栓形成的急性血管事件发病机制中发挥着非常重要的作用。这些动脉的阻塞导致心脏和脑组织局部缺血，进而引发心脏病发作和中风。半个多世纪以来，乙酰水杨酸（阿司匹林）一直是预防血栓形成事件一级和二级预防的首选药物。尽管阿司匹林作为预防血管血栓形成的抗血小板药物被广泛使用，但人们对其给予接受阿司匹林治疗患者的保护程度仍存在相当大的担忧。在本文中，我们解释了阿司匹林抵抗现象，讨论了阿司匹林治疗的局限性，并提出了监测“高危”个体的方法。监测和确定高危患者的能力将为临床医生提供定制抗血小板治疗的机会。
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