Department of Medical and Health Sciences-IMH, Radiation Physics, Linköping University, SE 581 85 Linköping, Sweden.
Phys Med Biol. 2012 Apr 21;57(8):2209-17. doi: 10.1088/0031-9155/57/8/2209. Epub 2012 Mar 29.
The aim of this study was to investigate signal fading in lithium formate electron paramagnetic resonance (EPR) dosimeters used for clinical applications in radiotherapy. A new experimental method for determination of signal fading, designed to resolve small changes in signal from slowly decaying unstable radicals, was used. Possible signal fading in lithium formate due to different storage temperatures was also tested. Air humidity was kept at a constant level of 33% throughout the experiments. The conclusion drawn from the investigations was that the EPR signal from lithium formate is stable during at least 1 month after irradiation and is not sensitive to variations in storage temperature <40 °C when kept at a relative air humidity of 33%. This makes lithium formate a suitable dosimeter for transfer dosimetry in clinical audits.
本研究旨在探讨用于放射治疗临床应用的甲酸锂电子顺磁共振（EPR）剂量计中的信号衰减现象。我们采用了一种新的实验方法来确定信号衰减，该方法旨在检测缓慢衰减的不稳定自由基的信号微小变化。此外，还测试了甲酸锂由于不同储存温度可能产生的信号衰减。在整个实验过程中，空气湿度保持在 33%的恒定水平。研究得出的结论是，甲酸锂的 EPR 信号在辐照后至少 1 个月内是稳定的，并且在相对空气湿度为 33%时，当储存温度<40°C 时，信号不敏感于变化，这使得甲酸锂成为临床审核中转移剂量测量的合适剂量计。
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