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抑郁症和共病酒精使用障碍的支持性短信:单盲随机试验。

Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial.

机构信息

Department of Psychiatry, Trinity College Dublin, St Patrick's University Hospital, Dublin 8, Ireland.

出版信息

J Affect Disord. 2012 Dec 10;141(2-3):168-76. doi: 10.1016/j.jad.2012.02.040. Epub 2012 Mar 29.

Abstract

BACKGROUND

Mobile phone text message technology has the potential to improve outcomes for patients with depression and co-morbid Alcohol Use Disorder (AUD).

AIMS

To perform a randomised rater-blinded trial to explore the effects of supportive text messages on mood and abstinence outcomes for patients with depression and co-morbid AUD.

METHODS

Participants (n=54) with a DSM IV diagnosis of unipolar depression and AUD who completed an in-patient dual diagnosis treatment programme were randomised to receive twice daily supportive text messages (n=26) or a fortnightly thank you text message (n=28) for three months. Primary outcome measures were Beck's Depression Inventory (BDI-II) scores and Cumulative Abstinence Duration (CAD) in days at three months.

TRIAL REGISTRATION

NCT0137868.

RESULTS

There was a statistically significant difference in three month BDI-II scores between the intervention and control groups; 8.5 (SD=8.0) vs. 16.7 (SD=10.3) respectively after adjusting for the baseline scores, F (1, 49)=9.54, p=0.003, η(p)(2)=0.17. The mean difference in change BDI-II scores was -7.9 (95% CI -13.06 to -2.76, Cohen'sd=0.85). There was a trend for a greater CAD in the text message group than the control group: 88.3 (SD=6.2) vs. 79.3 (SD=24.1), t=1.78, df=48, p=0.08.

LIMITATIONS

Limitations of the study include the small sample size, the potential for loss of rater blinding and the lack of long term follow-up to determine the longer term effects of the intervention.

CONCLUSION

Supportive text messages have the potential to improve outcomes for patients with comorbid depression and alcohol dependency syndrome.

摘要

背景

手机短信技术有可能改善患有抑郁症和合并酒精使用障碍(AUD)的患者的治疗效果。

目的

进行一项随机评估者盲法试验,以探讨支持性短信对患有抑郁症和合并 AUD 的患者的情绪和戒断结果的影响。

方法

参加者(n=54)患有 DSM-IV 诊断的单相抑郁症和 AUD,他们完成了住院双诊断治疗计划,被随机分配接受每日两次的支持性短信(n=26)或每两周的感谢短信(n=28),持续三个月。主要的结果测量是贝克抑郁量表(BDI-II)评分和三个月内的累积戒断持续时间(CAD)。

试验注册

NCT0137868。

结果

在调整基线评分后,干预组和对照组在三个月时的 BDI-II 评分有统计学上的显著差异;分别为 8.5(SD=8.0)和 16.7(SD=10.3),F(1,49)=9.54,p=0.003,η(p)(2)=0.17。BDI-II 评分变化的平均差异为-7.9(95%CI-13.06 至-2.76,Cohen'sd=0.85)。短信组的 CAD 比对照组有更大的趋势:88.3(SD=6.2)和 79.3(SD=24.1),t=1.78,df=48,p=0.08。

局限性

该研究的局限性包括样本量小、评估者盲法的潜在丧失以及缺乏长期随访以确定干预的长期效果。

结论

支持性短信有可能改善患有合并抑郁症和酒精依赖综合征的患者的治疗效果。

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