IgA 多发性骨髓瘤中的新月体性肾小球肾炎：一例报告
Crescentic glomerulonephritis in IgA multiple myeloma: a case report.
作者信息
Moscoso-Solorzano Grace T, Madureira-Silva Marcus V, Balda Carlos, Franco Marcello F, Mastroianni-Kirsztajn Gianna
机构信息
Glomerulopathy Section, Universidade Federal de São Paulo, São Paulo, Brazil.
出版信息
Nephron Extra. 2011 Jan;1(1):69-72. doi: 10.1159/000331217. Epub 2011 Sep 8.
BACKGROUND
There are few reports of glomerulonephritis (GN) with crescents and a rapidly progressive course that lead to a diagnosis of a previously unsuspected B-cell dyscrasia.
CASE PRESENTATION
We report a case of rapidly progressive GN: the patient showed no evidence of etiology at the time of biopsy and was diagnosed as IgA multiple myeloma (MM) during investigation based on a renal biopsy. He presented diffuse proliferative and exudative GN and marked plasma cell infiltration of the kidney.
CONCLUSION
The present case raises the possibility that proliferative GN with crescents may be a rare mode of presentation of MM.
背景
新月体性肾小球肾炎（GN）伴快速进展病程且导致诊断出先前未被怀疑的B细胞发育异常的报道较少。
病例报告
我们报告一例快速进展性GN病例：该患者活检时未发现病因证据，在基于肾活检的调查过程中被诊断为IgA型多发性骨髓瘤（MM）。他表现为弥漫性增殖性和渗出性GN以及肾脏明显的浆细胞浸润。
结论
本病例提示新月体性增殖性GN可能是MM一种罕见的表现形式。
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