[海洋海绵Phakellia fusca真菌PF18的次生代谢产物研究]

[Study on the secondary metabolites from the marine sponge Phakellia fusca fungi PF18].

作者信息

Tang Li-Dan, Liang Yuan-Wei, Liao Xiao-Jian, Liang Qiu, Xu Shi-Hai, Li Zhi-Yong

机构信息

Department of Chemistry, Jinan University, Guangzhou 510632,China.

出版信息

Zhong Yao Cai. 2011 Dec;34(12):1877-9.

PMID:22500421

Abstract

OBJECTIVE

To study the secondary metabolites from the marine sponge Phakellia fusca epiphytic fungi.

METHODS

The compounds were isolated by column chromatography over silica gel and purified by Sephadex LH-20 column chromatography and preparative TLC. The structures were elucidated by means of physiochemical properties and spectroscopic analyses.

RESULTS

Four compounds were separated and identified as: cyclo-(L-Val-L-Pro) (1), cyclo-(L-Phe-L-Pro) (2), cyclo-(L-Tyr-L-Pro) (3), cyclo-(3-hydroxy-4-methyldecanoyl-Gly-L-Val-D-Leu-L-Ala-L-Phe) (4).

CONCLUSION

Compounds 1-4 are obtained from the marine sponge Phakellia fusca epiphytic fungi for the first time.

摘要

目的

研究海洋海绵体深色软海绵附生真菌的次生代谢产物。

方法

通过硅胶柱色谱法分离化合物，并经葡聚糖凝胶LH - 20柱色谱法和制备薄层层析法进行纯化。借助理化性质和光谱分析对结构进行鉴定。

结果

分离并鉴定出四种化合物，分别为：环（L - 缬氨酸 - L - 脯氨酸）（1）、环（L - 苯丙氨酸 - L - 脯氨酸）（2）、环（L - 酪氨酸 - L - 脯氨酸）（3）、环（3 - 羟基 - 4 - 甲基癸酰基 - 甘氨酸 - L - 缬氨酸 - D - 亮氨酸 - L - 丙氨酸 - L - 苯丙氨酸）（4）。