异烟肼治疗 6 个月是否比治疗 9 个月更具成本效益？

Is isoniazid for 6 months more cost-effective than isoniazid for 9 months?

机构信息

Catalan Institute of Health, Department of Health, Generalitat of Catalonia, Barcelona, Spain.

出版信息

Int J Tuberc Lung Dis. 2012 Jun;16(6):768-73. doi: 10.5588/ijtld.11.0302. Epub 2012 Apr 9.

DOI:10.5588/ijtld.11.0302

PMID:22508169

Abstract

SETTING

The optimal treatment for latent tuberculosis infection consists of isoniazid (H, INH) for 9-12 months. Although INH for 6 months (6H) is more cost-effective than the 12-month regimen, the cost-effectiveness of the 6H regimen and that of INH for 9 months (9H) have not been compared.

OBJECTIVE

To compare the cost-effectiveness of treatment with 6H and 9H.

METHODS

Cost-effectiveness was evaluated using the ratio of the cost of preventing one tuberculosis case using 6H vs. 9H. The cost was estimated as the product of the number of patients to be treated to prevent one case using 6H or 9H × the cost of 6H or 9H.

RESULTS

A total of 1039 patients were studied. The number of patients that needed to be treated to prevent one case was 33 (95%CI 21-83) using 6H and 26 (95%CI 18-50) using 9H. The cost of 6H and 9H was respectively €444.34 and €578.26, and the cost ratio of preventing one case with 6H/9H was 0.98 (95%CI 0.6-1.5).

CONCLUSIONS

The cost-effectiveness of treatment with 6H and 9H is similar.

摘要

背景

潜伏性结核感染的最佳治疗方案包括异烟肼（H，INH）治疗 9-12 个月。虽然 6 个月异烟肼（6H）方案比 12 个月方案更具成本效益，但尚未比较 6H 方案和 9 个月异烟肼（9H）方案的成本效益。

目的

比较 6H 和 9H 治疗的成本效益。

方法

使用预防一例结核病所需的 6H 与 9H 的成本比来评估成本效益。成本估计为使用 6H 或 9H 预防一例所需的患者人数乘以 6H 或 9H 的成本。

结果

共研究了 1039 例患者。使用 6H 预防一例需要治疗的患者人数为 33（95%CI 21-83），使用 9H 为 26（95%CI 18-50）。6H 和 9H 的成本分别为 444.34 欧元和 578.26 欧元，预防一例病例的成本比为 6H/9H 为 0.98（95%CI 0.6-1.5）。