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脊柱关节炎髋关节受累的患病率和特征:275 例患者的单中心观察性研究。

Prevalence and characteristics of hip involvement in spondyloarthritis: a single-centre observational study of 275 patients.

机构信息

Paris Descartes University, Medicine Faculty, APHP, Cochin Hospital, Rheumatology B Department, Paris, France.

出版信息

Clin Exp Rheumatol. 2012 Jul-Aug;30(4):481-6. Epub 2012 Aug 29.

Abstract

OBJECTIVES

Hip involvement is a classic feature of spondyloarthritis (SpA). The aim of the present paper is to study the prevalence, clinical and radiological features of hip involvement, and the association with criteria for severity, in a cohort of patients with SpA in a tertiary care centre.

DESIGN

retrospective single centre observational study in 2010 of patients with definite SpA who underwent direct interview by a physician. Hip involvement was defined as hip pain considered related to SpA inflammation and confirmed radiographically. Other data collection: demographic data, SpA characteristics, treatments performed for hip involvement.

ANALYSIS

prevalence of hip involvement was analysed according to disease duration (Kaplan-Meyer). Multivariate Cox analysis compared patients with vs. without hip involvement over time.

RESULTS

In all, 275 SpA patients were assessed. The median age was 45 (IQR 35-55) years, the median SpA symptom duration 14 (7-25) years, 61% (169) were men, and 79% were HLA-B27 positive. Hip involvement was found in 18% (49) SpA patients, with already 13% after 5 years of disease duration and with frequent bilateral involvement (61%). Hip involvement was associated with non-Caucasian origin (p=0.05). Thirty-three percent (16/49) needed surgery (23 total joint replacements in all) with good functional results.

CONCLUSIONS

Hip involvement is a frequent manifestation in SpA (18%), often bilateral, and associated with non-Caucasian origin. One third of the patients needed total joint replacement. Physicians should be wary of hip pain in SpA patients and implement rapid diagnostic procedures in such cases.

摘要

目的

髋关节受累是脊柱关节炎(SpA)的典型特征。本研究旨在探讨三级医疗机构中 SpA 患者髋关节受累的患病率、临床和放射学特征,以及与严重程度标准的相关性。

设计

2010 年对在三级医疗机构接受直接医生访谈的明确 SpA 患者进行回顾性单中心观察性研究。髋关节受累定义为被认为与 SpA 炎症有关且经影像学证实的髋关节疼痛。其他数据收集:人口统计学数据、SpA 特征、髋关节受累的治疗。

分析

根据疾病持续时间(Kaplan-Meier)分析髋关节受累的患病率。多变量 Cox 分析比较了随时间髋关节受累患者与无髋关节受累患者的情况。

结果

共评估了 275 例 SpA 患者。年龄中位数为 45(IQR 35-55)岁,SpA 症状持续时间中位数为 14(7-25)年,61%(169 例)为男性,79%为 HLA-B27 阳性。18%(49 例)的 SpA 患者发现髋关节受累,疾病持续 5 年后已达到 13%,且常为双侧受累(61%)。髋关节受累与非白种人起源有关(p=0.05)。33%(16/49)需要手术(总共 23 例全髋关节置换术),功能结果良好。

结论

髋关节受累是 SpA 的常见表现(18%),常为双侧,且与非白种人起源有关。三分之一的患者需要进行全髋关节置换术。医生应警惕 SpA 患者的髋关节疼痛,并在这种情况下迅速进行诊断。

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